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Tbio
THBS1
Thrombospondin-1

Protein Summary
Description
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260356
  • ENSP00000260356
  • ENSG00000137801

Symbol
  • TSP
  • TSP1
  • TSP
  • THBS
  • TSP1
  • TSP-1
  • THBS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
protein domain
1
PubMedID
1
molecular function
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.89   (req: < 5)
Gene RIFs: 348   (req: <= 3)
Antibodies: 655   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1569.89   (req: >= 5)
Gene RIFs: 348   (req: > 3)
Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 83
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
27.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
27.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thrombospondin 1
VGNC:1597
453319
Macaque
thrombospondin 1
705413
Mouse
MGI:98737
21825
Dog
thrombospondin 1
VGNC:47335
487486
Horse
thrombospondin 1
VGNC:24072
100057478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thrombospondin 1
Macaque
thrombospondin 1
Mouse
Dog
thrombospondin 1
Horse
thrombospondin 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07996-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (135)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Extracellular matrix organization
Gene Ontology Terms (97)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (357)
1 – 10 of 357
THBS2
Tbio
Novelty: 0.00310724
p_int: 1
Score: 0.942
Data Source: BioPlex,STRINGDB
THBS3
Tbio
Novelty: 0.01915634
p_int: 0.999998576
p_ni: 4.9e-8
p_wrong: 0.000001376
Score: 0.238
Data Source: BioPlex,STRINGDB
FCGRT
Tchem
Novelty: 0.00105713
p_int: 0.9999972
p_ni: 0.0000028
Score: 0.191
Data Source: BioPlex,STRINGDB
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999969539
p_ni: 0.000030447
p_wrong: 1.3e-8
Data Source: BioPlex
CD47
Tchem
Novelty: 0.00129086
Score: 0.992
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.99
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.982
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.981
Data Source: STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
Score: 0.978
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00009007
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  1569.89

PubMed score by year
PubTator Score  2123.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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