Tbio ERCC1 DNA excision repair protein ERCC-1

Protein Summary

Description

Isoform 1: Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P07992
• B2RC01
• B3KRR0
• Q7Z7F5
• Q96S40

Gene Name

• ERCC1

Ensembl ID

• ENST00000013807
• ENSP00000013807
• ENSG00000012061
• ENST00000300853
• ENSP00000300853
• ENST00000340192
• ENSP00000345203
• ENST00000423698
• ENSP00000394875
• ENST00000589165
• ENSP00000468035

Symbol

• UV20
• COFS4
• RAD10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
disease perturbation	0.96
kinase perturbation	0.96
transcription factor perturbation	0.94
biological process	0.93

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endodeoxyribonuclease / Dna Excision Repair Protein Ercc-1

Protein / Nucleic Acid Binding / Dna Binding Protein / Endodeoxyribonuclease / Dna Excision Repair Protein Ercc-1

DTO Classes

Protein / Enzyme / Nuclease / Endodeoxyribonuclease / Dna Excision Repair Protein Ercc-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1430.47   (req: < 5)

Gene RIFs: 541   (req: <= 3)

Antibodies: 1117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1430.47   (req: >= 5)

Gene RIFs: 541   (req: > 3)

Antibodies: 1117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0