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Tbio
SFTPB
Pulmonary surfactant-associated protein B

Protein Summary
Description
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393822
  • ENSP00000377409
  • ENSG00000168878
  • ENST00000519937
  • ENSP00000428719

Symbol
  • SFTP3
  • SP-B
  • PSP-B
  • SFTB3
  • SFTP3
  • SMDP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological term
0.78
small molecule perturbation
0.75
disease
0.72
cellular component
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.88   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 660.88   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
SFTPC
Tbio
Novelty:  0.00154396
Score:  0.993
Data Source:  STRINGDB
SFTPA2
Tbio
Novelty:  0.00283745
Score:  0.99
Data Source:  STRINGDB
SFTPA1
Tbio
Novelty:  0.00530837
Score:  0.99
Data Source:  STRINGDB
SFTPD
Tbio
Novelty:  0.00120012
Score:  0.988
Data Source:  STRINGDB
CSF2RA
Tclin
Novelty:  0.00125121
Score:  0.962
Data Source:  STRINGDB
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
Score:  0.962
Data Source:  STRINGDB
NAPSA
Tbio
Family:  Enzyme
Novelty:  0.00486139
Score:  0.957
Data Source:  STRINGDB
CSF2RB
Tclin
Novelty:  0.02093804
Score:  0.937
Data Source:  STRINGDB
SFTA3
Tbio
Novelty:  0.00109932
Score:  0.932
Data Source:  STRINGDB
CCDC59
Tbio
Novelty:  0.05894885
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) (R-HSA-5688890)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Reactome
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Reactome
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
Reactome
Disease
Reactome
Diseases associated with surfactant metabolism
Name
Explore in Pharos
Explore in Source
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
Disease
Diseases associated with surfactant metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
1
1.1
97
4
3
1
1.1
95.6
blood protein measurement
3
4
5
90.2
granulysin measurement
1
2
2
77.9
serum gamma-glutamyl transferase measurement
2
2
2
61.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
97
1
1.1
95.6
blood protein measurement
5
90.2
granulysin measurement
2
77.9
serum gamma-glutamyl transferase measurement
2
61.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
surfactant protein B
696477
Mouse
MGI:109516
20388
Rat
RGD:621700
192155
Dog
surfactant protein B [Source:HGNC Symbol;Acc:HGNC:10801]
Horse
surfactant protein B
VGNC:22904
100034028
Species
Name
OMA
EggNOG
Inparanoid
Macaque
surfactant protein B
Mouse
Rat
Dog
surfactant protein B [Source:HGNC Symbol;Acc:HGNC:10801]
Horse
surfactant protein B
Publication Statistics
PubMed Score 660.88
PubMed score by year
PubTator Score 713.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title