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Tclin
LYN
Tyrosine-protein kinase Lyn

Protein Summary
Description
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519728
  • ENSP00000428924
  • ENSG00000254087
  • ENST00000520220
  • ENSP00000428424

Symbol
  • JTK8
  • JTK8
  • p53Lyn
  • p56Lyn
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
viral protein
1
virus
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 980.56   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 826   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 980.56   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 826   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 104
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 57
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
43.5
platelet count
1
1
1
32.2
mean reticulocyte volume
1
1
1
22.3
mean corpuscular volume
1
1
1
18.8
leukocyte count
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
43.5
platelet count
1
32.2
mean reticulocyte volume
1
22.3
mean corpuscular volume
1
18.8
leukocyte count
1
6.3
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (102)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Gene Ontology Terms (122)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (393)
1 – 10 of 393
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.916903057
p_ni: 0.083096943
Score: 0.367
Data Source: BioPlex,STRINGDB
NR2F6
Tbio
Family: NR
Novelty: 0.02314124
p_int: 0.782323902
p_ni: 0.217676098
Data Source: BioPlex
CD19
Tclin
Novelty: 0.0001816
Score: 0.994
Data Source: STRINGDB
CD22
Tclin
Novelty: 0.0009372
Score: 0.987
Data Source: Reactome,STRINGDB
LCP2
Tbio
Novelty: 0.00512968
Score: 0.987
Data Source: STRINGDB
CD79A
Tbio
Novelty: 0.00118942
Score: 0.986
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.985
Data Source: Reactome,STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.985
Data Source: Reactome,STRINGDB
PTPN6
Tchem
Family: Enzyme
Novelty: 0.00535749
Score: 0.984
Data Source: STRINGDB
HCLS1
Tbio
Novelty: 0.08304056
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  980.56

PubMed score by year
PubTator Score  476.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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