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Tclin
LYN
Tyrosine-protein kinase Lyn

Protein Summary
Description
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519728
  • ENSP00000428924
  • ENSG00000254087
  • ENST00000520220
  • ENSP00000428424

Symbol
  • JTK8
  • JTK8
  • p53Lyn
  • p56Lyn
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
viral protein
1
virus
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1119.88   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 826   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1119.88   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 826   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 104
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 108
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5