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Tclin
YES1
Tyrosine-protein kinase Yes

Protein Summary
Description
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314574
  • ENSP00000324740
  • ENSG00000176105
  • ENST00000584307
  • ENSP00000462468

Symbol
  • YES
  • Yes
  • c-yes
  • HsT441
  • P61-YES
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.97
protein domain
0.97
microRNA
0.87
biological process
0.86


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.79   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.79   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 55
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
62.2
diastolic blood pressure
1
1
1
46.4
thyroid peroxidase antibody measurement
1
1
1
44.1
anti-thyroglobulin antibody measurement
1
1
1
44.1
1
1
1
20.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
62.2
diastolic blood pressure
1
46.4
thyroid peroxidase antibody measurement
1
44.1
anti-thyroglobulin antibody measurement
1
44.1
1
20.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YES proto-oncogene 1, Src family tyrosine kinase
VGNC:10011
455322
Macaque
YES proto-oncogene 1, Src family tyrosine kinase
697099
Mouse
MGI:99147
22612
Rat
RGD:3977
24884
Dog
YES proto-oncogene 1, Src family tyrosine kinase
VGNC:48484
403917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YES proto-oncogene 1, Src family tyrosine kinase
Macaque
YES proto-oncogene 1, Src family tyrosine kinase
Mouse
Rat
Dog
YES proto-oncogene 1, Src family tyrosine kinase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07947-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (229)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
CD28 co-stimulation
Reactome
CTLA4 inhibitory signaling
Reactome
Cell surface interactions at the vascular wall
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
CD28 co-stimulation
CTLA4 inhibitory signaling
Cell surface interactions at the vascular wall
Gene Ontology Terms (33)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (234)
1 – 10 of 234
HSP90AB3P
Tdark
p_int: 0.999997088
p_ni: 0.000002911
p_wrong: 2e-9
Data Source: BioPlex
FGR
Tchem
Family: Kinase
Novelty: 0.00262848
p_int: 0.999993247
p_ni: 3e-9
p_wrong: 0.00000675
Score: 0.981
Data Source: BioPlex,STRINGDB
CCDC186
Tdark
Novelty: 0.44973807
p_int: 0.999959751
p_ni: 1.31e-7
p_wrong: 0.000040118
Score: 0.189
Data Source: BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int: 0.999922815
p_ni: 0.00007531
p_wrong: 0.000001875
Data Source: BioPlex
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
p_int: 0.999890557
p_ni: 0.000109443
Score: 0.999
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.999836212
p_ni: 0.000163788
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999707209
p_ni: 0.000292791
Data Source: BioPlex
PRUNE2
Tbio
Novelty: 0.05701865
p_int: 0.980434455
p_ni: 0.019565545
Score: 0.792
Data Source: BioPlex,STRINGDB
HOXB5
Tbio
Family: TF
Novelty: 0.01119871
p_int: 0.977335221
p_ni: 0.022664779
Data Source: BioPlex
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.975651455
p_ni: 0.024348545
Data Source: BioPlex
Publication Statistics
PubMed Score  164.79

PubMed score by year
PubTator Score  72.15

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer