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Tclin
YES1
Tyrosine-protein kinase Yes

Protein Summary
Description
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314574
  • ENSP00000324740
  • ENSG00000176105
  • ENST00000584307
  • ENSP00000462468

Symbol
  • YES
  • Yes
  • c-yes
  • HsT441
  • P61-YES
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.97
protein domain
0.97
microRNA
0.87
biological process
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.21   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.21   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4