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Tbio
UQCRH
Cytochrome b-c1 complex subunit 6, mitochondrial

Protein Summary
Description
This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311672
  • ENSP00000309565
  • ENSG00000173660

Symbol
  • QCR6
  • UQCR8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
disease perturbation
0.93
transcription factor binding site profile
0.84
transcription factor perturbation
0.8
tissue
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (206)
COX7A2L
Tbio
Family:  Enzyme
Novelty:  0.06920916
p_int:  0.999986582
p_ni:  0.000013367
p_wrong:  5.1e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
DOCK11
Tdark
Novelty:  0.0295159
p_int:  0.999984407
p_ni:  0.000015593
Score:  0.173
Data Source:  BioPlex,STRINGDB
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.999977319
p_ni:  0.000022303
p_wrong:  3.77e-7
Data Source:  BioPlex
UQCRB
Tbio
Novelty:  0.02933046
p_int:  0.999962875
p_ni:  0.000037125
Score:  0.999
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999945154
p_ni:  0.000054833
p_wrong:  1.4e-8
Score:  0.337
Data Source:  BioPlex,STRINGDB
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.99902491
p_ni:  0.00097509
Score:  0.191
Data Source:  BioPlex,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.996619836
p_ni:  0.003380048
p_wrong:  1.16e-7
Score:  0.484
Data Source:  BioPlex,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.995933005
p_ni:  0.00406241
p_wrong:  0.000004584
Score:  0.602
Data Source:  BioPlex,STRINGDB
MT-CYB
Tbio
Novelty:  0.00012093
p_int:  0.995231092
p_ni:  0.000298684
p_wrong:  0.004470224
Score:  0.999
Data Source:  BioPlex,STRINGDB
CYC1
Tchem
Novelty:  0.01369865
p_int:  0.987828044
p_ni:  0.012171956
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
N-acylethanolamine measurement
1
1
5
44.2
age at menopause
1
1
1
27.3
BMI-adjusted hip circumference
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
N-acylethanolamine measurement
5
44.2
age at menopause
1
27.3
BMI-adjusted hip circumference
1
24.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-c1 complex subunit 6, mitochondrial
742376
Mouse
MGI:1913826
66576
Rat
RGD:1305987
366448
Dog
ubiquinol-cytochrome c reductase hinge protein
608530
Horse
cytochrome b-c1 complex subunit 6, mitochondrial
100051878
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome b-c1 complex subunit 6, mitochondrial
Mouse
Rat
Dog
ubiquinol-cytochrome c reductase hinge protein
Horse
cytochrome b-c1 complex subunit 6, mitochondrial
Publication Statistics
PubMed Score 24.57
PubMed score by year
PubTator Score 6.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title