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Tbio
UMOD
Uromodulin

Protein Summary
Description
Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed:3498215). Facilitates neutrophil migration across renal epithelia (PubMed:20798515). Uromodulin, secreted form: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302509
  • ENSP00000306279
  • ENSG00000169344
  • ENST00000396134
  • ENSP00000379438
  • ENST00000570689
  • ENSP00000460548

Symbol
  • THP
  • FJHN
  • HNFJ
  • THGP
  • HNFJ1
  • MCKD2
  • ADMCKD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.93
biological term
0.78
phenotype
0.68
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 797.65   (req: < 5)
Gene RIFs: 109   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 797.65   (req: >= 5)
Gene RIFs: 109   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
B4GALNT2
Tbio
Family:  Enzyme
Novelty:  0.00499206
Score:  0.947
Data Source:  Reactome,STRINGDB
AQP2
Tbio
Novelty:  0.00088471
Score:  0.756
Data Source:  STRINGDB
SLC12A1
Tclin
Family:  Transporter
Novelty:  0.00303604
Score:  0.725
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.71
Data Source:  STRINGDB
SLC22A12
Tclin
Family:  Transporter
Novelty:  0.00318081
Score:  0.626
Data Source:  STRINGDB
GTPBP1
Tbio
Novelty:  0.00160825
Score:  0.624
Data Source:  STRINGDB
CD36
Tbio
Novelty:  0.00140825
Score:  0.616
Data Source:  STRINGDB
AMBP
Tbio
Novelty:  0.00183885
Score:  0.589
Data Source:  STRINGDB
KCNJ1
Tchem
Family:  IC
Novelty:  0.0025066
Score:  0.578
Data Source:  STRINGDB
SHROOM3
Tbio
Novelty:  0.02763602
Score:  0.571
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
20
12
20
1.7
99.9
creatinine measurement
10
8
11
4.4
99.8
urinary uromodulin measurement
3
5
5
99.5
4
3
3
1.2
99
creatine measurement
4
3
0
1.2
98.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
20
1.7
99.9
creatinine measurement
11
4.4
99.8
urinary uromodulin measurement
5
99.5
3
1.2
99
creatine measurement
0
1.2
98.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
uromodulin
695883
Mouse
MGI:102674
22242
Rat
RGD:3940
25128
Horse
uromodulin
100051746
Opossum
uromodulin
100026222
Species
Name
OMA
EggNOG
Inparanoid
Macaque
uromodulin
Mouse
Rat
Horse
uromodulin
Opossum
uromodulin
Publication Statistics
PubMed Score 797.65
PubMed score by year
PubTator Score 308.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title