Tbio HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2

Protein Summary

Description

Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07910
• D3DS19
• D3DS22
• P22628
• Q53EX2
• Q59FD3
• Q5FWE8
• Q86SF8
• Q86U45
• Q96HK7
• Q96HM4
• Q96IY5
• Q9BTS3
• hnRNP C1/C2

Gene Name

• HNRNPC

Ensembl ID

• ENST00000420743
• ENSP00000404848
• ENSG00000092199
• ENST00000430246
• ENSP00000442816
• ENST00000553300
• ENSP00000450544
• ENST00000554455
• ENSP00000451291
• ENST00000554969
• ENSP00000450725
• ENST00000555883
• ENSP00000450629
• ENST00000556628
• ENSP00000451652
• ENST00000556897
• ENSP00000451176
• ENST00000557201
• ENSP00000452276

Symbol

• HNRPC
• C1
• C2
• HNRNP
• HNRPC
• SNRPC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
drug perturbation	1
hub protein	1
interacting protein	1
ligand (protein) perturbation	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.09   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 430   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.09   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0