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Tbio
HNRNPC
Heterogeneous nuclear ribonucleoproteins C1/C2

Protein Summary
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420743
  • ENSP00000404848
  • ENSG00000092199
  • ENST00000430246
  • ENSP00000442816
  • ENST00000553300
  • ENSP00000450544
  • ENST00000554455
  • ENSP00000451291
  • ENST00000554969
  • ENSP00000450725
  • ENST00000555883
  • ENSP00000450629
  • ENST00000556628
  • ENSP00000451652
  • ENST00000556897
  • ENSP00000451176
  • ENST00000557201
  • ENSP00000452276

Symbol
  • HNRPC
  • C1
  • C2
  • HNRNP
  • HNRPC
  • SNRPC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
drug perturbation
1
hub protein
1
interacting protein
1
ligand (protein) perturbation
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.09   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 829.09   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0