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Tbio
GALT
Galactose-1-phosphate uridylyltransferase

Protein Summary
Description
Plays an important role in galactose metabolism. Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.11   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.11   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
UBTD2
Tbio
Novelty:  0.19609399
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.261
Data Source:  BioPlex,STRINGDB
NRBF2
Tbio
Novelty:  0.02432243
p_int:  0.999999445
p_ni:  5.55e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
ARPC3
Tbio
Novelty:  0.02951522
p_int:  0.999981693
p_ni:  0.000018267
p_wrong:  4e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
HLA-DQA1
Tbio
Novelty:  0.00077488
p_int:  0.999652656
p_ni:  0.00018898
p_wrong:  0.000158364
Score:  0.228
Data Source:  BioPlex,STRINGDB
NIF3L1
Tbio
Novelty:  0.15581813
p_int:  0.996822937
p_ni:  0.003177063
Data Source:  BioPlex
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.999
Data Source:  STRINGDB
GALK1
Tbio
Family:  Kinase
Novelty:  0.00156677
Score:  0.999
Data Source:  STRINGDB
UGP2
Tbio
Family:  Enzyme
Novelty:  0.00760963
Score:  0.987
Data Source:  STRINGDB
PGM1
Tbio
Family:  Enzyme
Novelty:  0.00163947
Score:  0.955
Data Source:  STRINGDB
GALK2
Tbio
Family:  Kinase
Novelty:  0.06382824
Score:  0.948
Data Source:  STRINGDB
Pathways (16)
Defective GALT can cause Galactosemia (R-HSA-5609978)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective GALT can cause Galactosemia
Reactome
Disease
Reactome
Diseases associated with glycosylation precursor biosynthesis
Reactome
Diseases of glycosylation
Reactome
Galactose catabolism
Name
Explore in Pharos
Explore in Source
Defective GALT can cause Galactosemia
Disease
Diseases associated with glycosylation precursor biosynthesis
Diseases of glycosylation
Galactose catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
1
1
80.5
7
3
2
1.1
77
adolescent idiopathic scoliosis
2
1
0
1.1
42.3
testosterone measurement
1
1
1
29
self reported educational attainment
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemokine (C-C motif) ligand 27 measurement
1
80.5
2
1.1
77
adolescent idiopathic scoliosis
0
1.1
42.3
testosterone measurement
1
29
self reported educational attainment
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95638
14430
Rat
RGD:1306483
298003
Dog
galactose-1-phosphate uridylyltransferase
VGNC:41103
474751
Horse
galactose-1-phosphate uridylyltransferase
VGNC:18238
100068493
Cow
galactose-1-phosphate uridylyltransferase
VGNC:29242
506997
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
galactose-1-phosphate uridylyltransferase
Horse
galactose-1-phosphate uridylyltransferase
Cow
galactose-1-phosphate uridylyltransferase
Publication Statistics
PubMed Score 89.11
PubMed score by year
PubTator Score 536.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title