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Tchem
HSP90AA1
Heat shock protein HSP 90-alpha

Protein Summary
Description
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chap ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216281
  • ENSP00000216281
  • ENSG00000080824
  • ENST00000334701
  • ENSP00000335153

Symbol
  • HSP90A
  • HSPC1
  • HSPCA
  • EL52
  • HSPN
  • LAP2
  • HSP86
  • HSPC1
  • HSPCA
  • Hsp89
  • Hsp90
  • LAP-2
  • HSP89A
  • HSP90A
  • HSP90N
  • Hsp103
  • HSPCAL1
  • HSPCAL4
  • HEL-S-65p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
hub protein
1
interacting protein
1
molecular function
1
disease perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7152.23   (req: < 5)
Gene RIFs: 395   (req: <= 3)
Antibodies: 1647   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7152.23   (req: >= 5)
Gene RIFs: 395   (req: > 3)
Antibodies: 1647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1134
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4