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Tchem
HSP90AA1
Heat shock protein HSP 90-alpha

Protein Summary
Description
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chap ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216281
  • ENSP00000216281
  • ENSG00000080824
  • ENST00000334701
  • ENSP00000335153

Symbol
  • HSP90A
  • HSPC1
  • HSPCA
  • EL52
  • HSPN
  • LAP2
  • HSP86
  • HSPC1
  • HSPCA
  • Hsp89
  • Hsp90
  • LAP-2
  • HSP89A
  • HSP90A
  • HSP90N
  • Hsp103
  • HSPCAL1
  • HSPCAL4
  • HEL-S-65p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
hub protein
1
interacting protein
1
molecular function
1
disease perturbation
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6521.41   (req: < 5)
Gene RIFs: 395   (req: <= 3)
Antibodies: 1647   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6521.41   (req: >= 5)
Gene RIFs: 395   (req: > 3)
Antibodies: 1647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1052
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
4
96.2
urate measurement
1
1
1
62.1
reticulocyte count
2
1
2
47.7
reticulocyte measurement
2
1
2
42.3
platelet crit
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
96.2
urate measurement
1
62.1
reticulocyte count
2
47.7
reticulocyte measurement
2
42.3
platelet crit
1
42.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein 90 alpha family class A member 1
VGNC:12785
743883
Mouse
MGI:96250
15519
Rat
RGD:631409
299331
Horse
heat shock protein 90 alpha family class A member 1
100033837
Cow
heat shock protein 90 alpha family class A member 1
VGNC:53940
281832
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein 90 alpha family class A member 1
Mouse
Rat
Horse
heat shock protein 90 alpha family class A member 1
Cow
heat shock protein 90 alpha family class A member 1
Protein Structure (286 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07900-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 286
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (351)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 75
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Attenuation phase
Reactome
Autophagy
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Attenuation phase
Autophagy
Axon guidance
Gene Ontology Terms (81)
Items per page:
10
1 – 10 of 20
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (1131)
1 – 10 of 1131
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.999660179
p_ni:  0.000339821
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
CDK9
Tchem
Family:  Kinase
Novelty:  0.00210218
p_int:  0.999611252
p_ni:  0.000388748
Score:  0.607
Data Source:  BioPlex,STRINGDB
STK11
Tchem
Family:  Kinase
Novelty:  0.00073247
p_int:  0.999239487
p_ni:  0.000760513
Score:  0.959
Data Source:  BioPlex,STRINGDB
RPS6KA4
Tchem
Family:  Kinase
Novelty:  0.05213255
p_int:  0.997527817
p_ni:  0.002472183
Data Source:  BioPlex
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
p_int:  0.997043726
p_ni:  0.002956274
Score:  0.855
Data Source:  BioPlex,STRINGDB
CDK7
Tchem
Family:  Kinase
Novelty:  0.00322814
p_int:  0.996888042
p_ni:  0.003111958
Score:  0.38
Data Source:  BioPlex,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
p_int:  0.99601604
p_ni:  0.00398396
Score:  0.907
Data Source:  BioPlex,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.994959633
p_ni:  0.005040367
Score:  0.6
Data Source:  BioPlex,STRINGDB
SMYD3
Tchem
Family:  Epigenetic
Novelty:  0.01040802
p_int:  0.994797126
p_ni:  0.005202874
Score:  0.709
Data Source:  BioPlex,STRINGDB
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.994216901
p_ni:  0.005783099
Score:  0.309
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6521.41

PubMed score by year
PubTator Score  2994.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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