Tbio LDHC L-lactate dehydrogenase C chain

Protein Summary

Description

Possible role in sperm motility. Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07864
• D3DQY4
• Q6GSG8
• Q7Z7J4
• LDH-C

Gene Name

• LDHC

Ensembl ID

• ENST00000280704
• ENSP00000280704
• ENSG00000166796
• ENST00000541669
• ENSP00000437783

Symbol

• LDH3
• LDHX
• CT32
• LDH3
• LDHX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
cell type or tissue	0.89
kinase perturbation	0.76
biological process	0.71
gene perturbation	0.53

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / L-lactate Dehydrogenase C Chain

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / L-lactate Dehydrogenase C Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.99   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 230   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.99   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0