Tchem CTSB Cathepsin B

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Cathepsin B

Protein / ... / Protease Inhibitor / Cathepsin B

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Cathepsin B

Protein Summary

Description

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P07858
• B3KQR5
• B3KRR5
• Q503A6
• Q96D87

Gene Name

• CTSB

Ensembl ID

• ENST00000345125
• ENSP00000342070
• ENSG00000164733
• ENST00000353047
• ENSP00000345672
• ENST00000453527
• ENSP00000409917
• ENST00000530640
• ENSP00000435105
• ENST00000531089
• ENSP00000433215
• ENST00000533455
• ENSP00000432244
• ENST00000534510
• ENSP00000434217

Symbol

• CPSB
• APPS
• CPSB
• RECEUP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
biological term	0.98
disease perturbation	0.98
cellular component	0.96

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3822.77   (req: < 5)

Gene RIFs: 211   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3822.77   (req: >= 5)

Gene RIFs: 211   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 490

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

telaprevir

CTSBTchem Enzyme

IC50 : 6.68

Active Ligands (490)

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1 – 10 of 490

CHEMBL230474

CTSBTchem Enzyme

IC50 : 8.3

CHEMBL390474

CTSBTchem Enzyme

IC50 : 9

CHEMBL374508

CTSBTchem Enzyme

IC50 : 8.3

CHEMBL1288531

CTSBTchem Enzyme

IC50 : 7.39

CHEMBL1288530

CTSBTchem Enzyme

IC50 : 6.84

CHEMBL390475

CTSBTchem Enzyme

IC50 : 8.7

CHEMBL286364

CTSBTchem Enzyme

Ki : 6.3

CHEMBL3648398

CTSBTchem Enzyme

Ki : 6.11

CHEMBL3648411

CTSBTchem Enzyme

Ki : 6.36

CHEMBL1288532

CTSBTchem Enzyme

IC50 : 7.06

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	2	2	2		89.6
heel bone mineral density	EFO_0009270	1	1	1		85.7
Parkinson's disease	EFO_0002508	2	2	1	1.1	72
basophil percentage of leukocytes	EFO_0007992	1	1	1		17.3
basophil count	EFO_0005090	1	1	1		10.7

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	2		89.6
heel bone mineral density	EFO_0009270	1		85.7
Parkinson's disease	EFO_0002508	1	1.1	72
basophil percentage of leukocytes	EFO_0007992	1		17.3
basophil count	EFO_0005090	1		10.7

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cathepsin B	VGNC:897	463993
Macaque	cathepsin B		100424758
Mouse	cathepsin B	MGI:88561	13030
Rat	cathepsin B	RGD:621509	64529
Dog	cathepsin B	VGNC:39709	486077

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cathepsin B
Macaque	cathepsin B
Mouse	cathepsin B
Rat	cathepsin B
Dog	cathepsin B

Protein Data Bank (14)

1 – 5 of 14

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (25)

Reactome (12)

KEGG (6)

PathwayCommons (1)

WikiPathways (6)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Collagen degradation	40 targets	R-HSA-1442490
Collagen formation	90 targets	R-HSA-1474290
Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Gene Ontology Terms (28)

Functions (6)

Components (12)

Processes (10)

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GO Term	Evidence	Assigned by
collagen binding	Inferred from Direct Assay (IDA)	BHF-UCL
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	BHF-UCL
cysteine-type peptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
peptidase activity	Inferred from Direct Assay (IDA)	BHF-UCL
proteoglycan binding	Inferred from Physical Interaction (IPI)	BHF-UCL
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (239)

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1 – 10 of 239

• See Interactions on String-DB

CSTA

Tbio

Novelty: 0.00453121

p_int: 0.969600772

p_ni: 0.030399228

Score: 0.977

Data Source: BioPlex,STRINGDB

CTSD

Tchem

Family: Enzyme

Novelty: 0.00029823

Score: 0.97

Data Source: STRINGDB

CD74

Tchem

Novelty: 0.00281228

Score: 0.942

Data Source: STRINGDB

TLR7

Tclin

Novelty: 0.00067036

Score: 0.941

Data Source: STRINGDB

NLRP3

Tchem

Novelty: 0.00043957

Score: 0.939

Data Source: STRINGDB

COL18A1

Tbio

Novelty: 0.00074602

Score: 0.922

Data Source: STRINGDB

HLA-DQA1

Tbio

Novelty: 0.00077488

Score: 0.919

Data Source: STRINGDB

HLA-DRB1

Tbio

Novelty: 0.00240724

Score: 0.912

Data Source: STRINGDB

HLA-DRB1

Tbio

Novelty: 0.00240724

Score: 0.912

Data Source: STRINGDB

HLA-DRB1

Tchem

Novelty: 0.00240724

Score: 0.912

Data Source: STRINGDB

Publication Statistics

PubMed Score  3822.77

PubMed score by year

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PubTator Score  2672.59

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Protease

GWAS Trait Find Similar Targets

basophil count
basophil percentage of leukocytes
heel bone mineral density
leprosy
Parkinson's disease
risk-taking behaviour
triglyceride measurement

MGI Phenotype Find Similar Targets

cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
immune system phenotype