Tchem CTSB Cathepsin B

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Cathepsin B

Protein / ... / Protease Inhibitor / Cathepsin B

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Cathepsin B

Protein Summary

Description

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P07858
• B3KQR5
• B3KRR5
• Q503A6
• Q96D87

Gene Name

• CTSB

Ensembl ID

• ENST00000345125
• ENSP00000342070
• ENSG00000164733
• ENST00000353047
• ENSP00000345672
• ENST00000453527
• ENSP00000409917
• ENST00000530640
• ENSP00000435105
• ENST00000531089
• ENSP00000433215
• ENST00000533455
• ENSP00000432244
• ENST00000534510
• ENSP00000434217

Symbol

• CPSB
• APPS
• CPSB
• RECEUP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	0.99
biological term	0.98
disease perturbation	0.98
cellular component	0.96

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3920.49   (req: < 5)

Gene RIFs: 211   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3920.49   (req: >= 5)

Gene RIFs: 211   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 521

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

telaprevir

CTSBTchem Enzyme

IC50 : 6.68

Active Ligands (521)

Explore Active Ligands

1 – 10 of 521

CHEMBL390474

CTSBTchem Enzyme

IC50 : 9

CHEMBL230474

CTSBTchem Enzyme

IC50 : 8.3

L-trans-epoxysuccinylleucylamido(4-guanidino)-butane

CTSBTchem Enzyme

IC50 : 8.3

CHEMBL1288531

CTSBTchem Enzyme

IC50 : 7.39

CHEMBL1288530

CTSBTchem Enzyme

IC50 : 6.84

(R)-N-(Benzoyl)-S-(isobutyl)cysteinylsulfone-methylazaalanine-nitrile

CTSBTchem Enzyme

Ki : 8.24

relacatib

CTSBTchem Enzyme

Ki : 7.89

CHEMBL230478

CTSBTchem Enzyme

IC50 : 8.1

CHEMBL390475

CTSBTchem Enzyme

IC50 : 8.7

CHEMBL399361

CTSBTchem Enzyme

IC50 : 6.79

GWAS Traits (38)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 38

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	3	5	5		93
triglyceride measurement	EFO_0004530	5	4	5		91.1
reticulocyte count	EFO_0007986	2	2	2		84.7
BMI-adjusted waist circumference	EFO_0007789	2	13	15		82.8
reticulocyte measurement	EFO_0010700	2	2	2		82.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 38

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	5		93
triglyceride measurement	EFO_0004530	5		91.1
reticulocyte count	EFO_0007986	2		84.7
BMI-adjusted waist circumference	EFO_0007789	15		82.8
reticulocyte measurement	EFO_0010700	2		82.7

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cathepsin B	VGNC:897	463993
Macaque	cathepsin B		100424758
Mouse	cathepsin B	MGI:88561	13030
Rat	cathepsin B	RGD:621509	64529
Dog	cathepsin B	VGNC:39709	486077

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cathepsin B
Macaque	cathepsin B
Mouse	cathepsin B
Rat	cathepsin B
Dog	cathepsin B

Protein Structure (14 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (25)

Reactome (12)

KEGG (6)

PathwayCommons (1)

WikiPathways (6)

Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Collagen degradation	40 targets	R-HSA-1442490
Collagen formation	90 targets	R-HSA-1474290
Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Gene Ontology Terms (28)

Functions (6)

Components (12)

Processes (10)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
collagen binding	Inferred from Direct Assay (IDA)	BHF-UCL
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	BHF-UCL
cysteine-type peptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
peptidase activity	Inferred from Direct Assay (IDA)	BHF-UCL
proteoglycan binding	Inferred from Physical Interaction (IPI)	BHF-UCL
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (239)

Explore Interacting Targets

1 – 10 of 239

• See Interactions on String-DB

CSTA

Tbio

Novelty:  0.00453121

p_int:  0.969600772

p_ni:  0.030399228

Score:  0.977

Data Source:  BioPlex,STRINGDB

CTSD

Tchem

Family:  Enzyme

Novelty:  0.00029823

Score:  0.97

Data Source:  STRINGDB

CD74

Tchem

Novelty:  0.00281228

Score:  0.942

Data Source:  STRINGDB

TLR7

Tclin

Novelty:  0.00067036

Score:  0.941

Data Source:  STRINGDB

NLRP3

Tchem

Novelty:  0.00043957

Score:  0.939

Data Source:  STRINGDB

COL18A1

Tbio

Novelty:  0.00074602

Score:  0.922

Data Source:  STRINGDB

HLA-DQA1

Tbio

Novelty:  0.00077488

Score:  0.919

Data Source:  STRINGDB

HLA-DRB1

Tbio

Novelty:  0.00240724

Score:  0.912

Data Source:  STRINGDB

HLA-DRB1

Tbio

Novelty:  0.00240724

Score:  0.912

Data Source:  STRINGDB

HLA-DRB1

Tbio

Novelty:  0.00240724

Score:  0.912

Data Source:  STRINGDB

Publication Statistics

PubMed Score  3920.49

PubMed score by year

Reset Zoom

PubTator Score  2672.59

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Protease

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
appendicular lean mass
basophil count
basophil percentage of leukocytes
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
C-reactive protein measurement
Calcium channel blocker use measurement
creatinine measurement
diet measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
immune system phenotype