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Tchem
CTSB
Cathepsin B

Protein Summary
Description
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345125
  • ENSP00000342070
  • ENSG00000164733
  • ENST00000353047
  • ENSP00000345672
  • ENST00000453527
  • ENSP00000409917
  • ENST00000530640
  • ENSP00000435105
  • ENST00000531089
  • ENSP00000433215
  • ENST00000533455
  • ENSP00000432244
  • ENST00000534510
  • ENSP00000434217

Symbol
  • CPSB
  • APPS
  • CPSB
  • RECEUP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
biological term
0.98
disease perturbation
0.98
cellular component
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3920.49   (req: < 5)
Gene RIFs: 211   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3920.49   (req: >= 5)
Gene RIFs: 211   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 521
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
telaprevir
Rendered image for telaprevir
Active Ligands (521)
1 – 10 of 521
CHEMBL390474
Rendered image for CHEMBL390474
CHEMBL230474
Rendered image for CHEMBL230474
CHEMBL1288531
Rendered image for CHEMBL1288531
CHEMBL1288530
Rendered image for CHEMBL1288530
relacatib
Rendered image for relacatib
CHEMBL230478
Rendered image for CHEMBL230478
CHEMBL390475
Rendered image for CHEMBL390475
CHEMBL399361
Rendered image for CHEMBL399361
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
5
5
93
triglyceride measurement
5
4
5
91.1
reticulocyte count
2
2
2
84.7
BMI-adjusted waist circumference
2
13
15
82.8
reticulocyte measurement
2
2
2
82.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
93
triglyceride measurement
5
91.1
reticulocyte count
2
84.7
BMI-adjusted waist circumference
15
82.8
reticulocyte measurement
2
82.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin B
VGNC:897
463993
Macaque
cathepsin B
100424758
Mouse
MGI:88561
13030
Rat
RGD:621509
64529
Dog
cathepsin B
VGNC:39709
486077
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin B
Macaque
cathepsin B
Mouse
Rat
Dog
cathepsin B
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Assembly of collagen fibrils and other multimeric structures
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (239)
1 – 10 of 239
CSTA
Tbio
Novelty:  0.00453121
p_int:  0.969600772
p_ni:  0.030399228
Score:  0.977
Data Source:  BioPlex,STRINGDB
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
Score:  0.97
Data Source:  STRINGDB
CD74
Tchem
Novelty:  0.00281228
Score:  0.942
Data Source:  STRINGDB
TLR7
Tclin
Novelty:  0.00067036
Score:  0.941
Data Source:  STRINGDB
NLRP3
Tchem
Novelty:  0.00043957
Score:  0.939
Data Source:  STRINGDB
COL18A1
Tbio
Novelty:  0.00074602
Score:  0.922
Data Source:  STRINGDB
HLA-DQA1
Tbio
Novelty:  0.00077488
Score:  0.919
Data Source:  STRINGDB
HLA-DRB1
Tbio
Novelty:  0.00240724
Score:  0.912
Data Source:  STRINGDB
HLA-DRB1
Tbio
Novelty:  0.00240724
Score:  0.912
Data Source:  STRINGDB
HLA-DRB1
Tbio
Novelty:  0.00240724
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3920.49

PubMed score by year
PubTator Score  2672.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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