Protein Summary
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be ...more
- ENST00000345125
- ENSP00000342070
- ENSG00000164733
- ENST00000353047
- ENSP00000345672
- ENST00000453527
- ENSP00000409917
- ENST00000530640
- ENSP00000435105
- ENST00000531089
- ENSP00000433215
- ENST00000533455
- ENSP00000432244
- ENST00000534510
- ENSP00000434217
- CPSB
- APPS
- CPSB
- RECEUP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 0.99 | ||
biological term | 0.98 | ||
disease perturbation | 0.98 | ||
cellular component | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3920.49 (req: < 5)
Gene RIFs: 211 (req: <= 3)
Antibodies: 578 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3920.49 (req: >= 5)
Gene RIFs: 211 (req: > 3)
Antibodies: 578 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 521
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (521)
Protein-Protein Interactions (239)
CSTA
Novelty: 0.00453121
p_int: 0.969600772
p_ni: 0.030399228
Score: 0.977
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (25)
Reactome (12)
KEGG (6)
PathwayCommons (1)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen degradation | ||||
Reactome | Collagen formation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen degradation | ||||
Collagen formation | ||||
Degradation of the extracellular matrix | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (12)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 3 | 5 | 5 | 93 | |||||
triglyceride measurement | 5 | 4 | 5 | 91.1 | |||||
reticulocyte count | 2 | 2 | 2 | 84.7 | |||||
BMI-adjusted waist circumference | 2 | 13 | 15 | 82.8 | |||||
reticulocyte measurement | 2 | 2 | 2 | 82.7 | |||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 5 | 93 | |||||
triglyceride measurement | 5 | 91.1 | |||||
reticulocyte count | 2 | 84.7 | |||||
BMI-adjusted waist circumference | 15 | 82.8 | |||||
reticulocyte measurement | 2 | 82.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cathepsin B | VGNC:897 | 463993 | |||||
Macaque | cathepsin B | 100424758 | ||||||
Mouse | MGI:88561 | 13030 | ||||||
Rat | RGD:621509 | 64529 | ||||||
Dog | cathepsin B | VGNC:39709 | 486077 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cathepsin B | |||||
Macaque | cathepsin B | |||||
Mouse | ||||||
Rat | ||||||
Dog | cathepsin B | |||||
Publication Statistics
PubMed Score 3920.49
PubMed score by year
PubTator Score 2672.59
PubTator score by year
Related Publications
Text Mined References (298)
GeneRif Annotations (211)
Items per page:
0 of 0
PMID | Year | Title |
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