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Tchem
EPRS
Bifunctional glutamate/proline--tRNA ligase

Protein Classes
Protein Summary
Description
Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (PubMed:1756734, PubMed:24100331, PubMed:23263184). The phosphorylation of EPRS, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex and recruits it to the GAIT complex that binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin), suppressing their translation. Interferon-gamma can therefore redirect, in specific cells, the EPRS function from protein synthesis to translation inhibition (PubMed:15479637, PubMed:23071094). Also functions as an effector of the mTORC1 signaling pathway by promotin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366923
  • ENSP00000355890
  • ENSG00000136628

Symbol
  • GLNS
  • PARS
  • QARS
  • QPRS
  • EARS
  • PARS
  • QARS
  • QPRS
  • HLD15
  • PIG32
  • GLUPRORS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
disease perturbation
0.99
hub protein
0.96
molecular function
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1145.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL357355
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
67.4
reticulocyte count
3
1
3
50.9
glomerular filtration rate
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
67.4
reticulocyte count
3
50.9
glomerular filtration rate
1
1
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamyl-prolyl-tRNA synthetase
VGNC:1235
457746
Macaque
glutamyl-prolyl-tRNA synthetase
706899
Mouse
MGI:97838
107508
Rat
RGD:1310952
289352
Dog
glutamyl-prolyl-tRNA synthetase
VGNC:40425
478962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamyl-prolyl-tRNA synthetase
Macaque
glutamyl-prolyl-tRNA synthetase
Mouse
Rat
Dog
glutamyl-prolyl-tRNA synthetase
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07814-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (50)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of RNA
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of RNA
Metabolism of amino acids and derivatives
Metabolism of proteins
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (710)
1 – 10 of 710
KARS
Tchem
Family: Enzyme
Novelty: 0.00386511
p_int: 0.998884029
p_ni: 0.001115971
Score: 0.999
Data Source: BioPlex,STRINGDB
AIMP1
Tbio
Family: Enzyme
Novelty: 0.00743447
p_int: 0.996684787
p_ni: 0.003315213
Score: 0.999
Data Source: BioPlex,STRINGDB
RARS
Tchem
Family: Enzyme
Novelty: 0.00099479
p_int: 0.993858166
p_ni: 0.006141834
Score: 0.999
Data Source: BioPlex,STRINGDB
LARS
Tchem
Family: Enzyme
Novelty: 0.00361711
p_int: 0.989037048
p_ni: 0.010962952
Score: 0.999
Data Source: BioPlex,STRINGDB
QARS
Tchem
Family: Enzyme
Novelty: 0.01684657
p_int: 0.975918754
p_ni: 0.024081246
Score: 0.998
Data Source: BioPlex,STRINGDB
SDCBP
Tbio
Novelty: 0.00242211
p_int: 0.953067398
p_ni: 0.046932602
Score: 0.809
Data Source: BioPlex,STRINGDB
AIMP2
Tbio
Family: Enzyme
Novelty: 0.03283387
Score: 0.999
Data Source: STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.999
Data Source: STRINGDB
EEF1E1
Tbio
Novelty: 0.06216577
Score: 0.999
Data Source: STRINGDB
DARS
Tbio
Family: Enzyme
Novelty: 0.01101888
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  1145.63

PubMed score by year
PubTator Score  53.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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