EPRS
Bifunctional glutamate/proline--tRNA ligase
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 1 | ||
protein domain | 1 | ||
disease perturbation | 0.99 | ||
hub protein | 0.96 | ||
molecular function | 0.95 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic tRNA aminoacylation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic tRNA aminoacylation | ||||
Metabolism | ||||
Metabolism of RNA | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of proteins | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 7 | 4 | 7 | 93.1 | |||||
heel bone mineral density | 3 | 2 | 4 | 92.4 | |||||
reticulocyte measurement | 3 | 2 | 3 | 90.6 | |||||
red blood cell distribution width | 2 | 2 | 2 | 86.2 | |||||
aspartate aminotransferase measurement | 1 | 1 | 1 | 80.1 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte count | 7 | 93.1 | |||||
heel bone mineral density | 4 | 92.4 | |||||
reticulocyte measurement | 3 | 90.6 | |||||
red blood cell distribution width | 2 | 86.2 | |||||
aspartate aminotransferase measurement | 1 | 80.1 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | glutamyl-prolyl-tRNA synthetase | VGNC:1235 | 457746 | |||||
Macaque | glutamyl-prolyl-tRNA synthetase | 706899 | ||||||
Mouse | MGI:97838 | 107508 | ||||||
Rat | RGD:1310952 | 289352 | ||||||
Dog | glutamyl-prolyl-tRNA synthetase | VGNC:40425 | 478962 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | glutamyl-prolyl-tRNA synthetase | |||||
Macaque | glutamyl-prolyl-tRNA synthetase | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamyl-prolyl-tRNA synthetase | |||||
PMID | Year | Title |
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