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Tclin
CD3E
T-cell surface glycoprotein CD3 epsilon chain

Protein Summary
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361763
  • ENSP00000354566
  • ENSG00000198851

Symbol
  • T3E
  • T3E
  • TCRE
  • IMD18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
cell type or tissue
0.84
molecular function
0.79
tissue sample
0.65
gene perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.59   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 3578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.59   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 3578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Downstream TCR signaling
Generation of second messenger molecules
Immune System
Gene Ontology Terms (48)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (277)
1 – 10 of 277
HLA-A
Tbio
Novelty: 0.00378961
p_int: 0.991385168
p_ni: 0.008614832
Score: 0.926
Data Source: BioPlex,STRINGDB
LNPEP
Tchem
Family: Enzyme
Novelty: 0.00264352
p_int: 0.970820099
p_ni: 0.029179901
Score: 0.193
Data Source: BioPlex,STRINGDB
GHDC
Tbio
Novelty: 0.14562067
p_int: 0.938037008
p_ni: 0.061962992
Score: 0.19
Data Source: BioPlex,STRINGDB
TM2D3
Tbio
Novelty: 0.13870542
p_int: 0.868606626
p_ni: 0.130967764
p_wrong: 0.00042561
Score: 0.167
Data Source: BioPlex,STRINGDB
FAM241B
Tdark
Novelty: 2.47058824
p_int: 0.849545506
p_ni: 0.150454321
p_wrong: 1.73e-7
Score: 0.204
Data Source: BioPlex,STRINGDB
GP1BB
Tbio
Novelty: 0.01542416
p_int: 0.81660985
p_ni: 0.183379236
p_wrong: 0.000010914
Score: 0.161
Data Source: BioPlex,STRINGDB
CD3D
Tclin
Novelty: 0.00372579
Score: 0.999
Data Source: Reactome,STRINGDB
CD3G
Tclin
Novelty: 0.00498635
Score: 0.994
Data Source: Reactome,STRINGDB
CD247
Tbio
Novelty: 0.00275443
Score: 0.991
Data Source: Reactome,STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.00136499
Score: 0.99
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  187.59

PubMed score by year
PubTator Score  186.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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