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Tchem
APRT
Adenine phosphoribosyltransferase

Protein Summary
Description
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378364
  • ENSP00000367615
  • ENSG00000198931
  • ENST00000426324
  • ENSP00000397007

Symbol
  • AMP
  • APRTD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.83
disease perturbation
0.83
interacting protein
0.82
histone modification site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.28   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.28   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
crenolanib
Rendered image for crenolanib
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
5
9
10
99.3
HbA1c measurement
6
10
11
98.8
mean corpuscular hemoglobin concentration
7
5
9
98.2
reticulocyte count
6
9
16
97.7
hematocrit
4
6
7
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
10
99.3
HbA1c measurement
11
98.8
mean corpuscular hemoglobin concentration
9
98.2
reticulocyte count
16
97.7
hematocrit
7
97.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenine phosphoribosyltransferase
VGNC:5673
736305
Macaque
adenine phosphoribosyltransferase
697715
Mouse
MGI:88061
11821
Rat
RGD:1307758
292072
Dog
adenine phosphoribosyltransferase
VGNC:38014
479615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenine phosphoribosyltransferase
Macaque
adenine phosphoribosyltransferase
Mouse
Rat
Dog
adenine phosphoribosyltransferase
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07741-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of nucleotides
Neutrophil degranulation
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (253)
1 – 10 of 253
UNC45B
Tbio
Novelty:  0.01872121
p_int:  0.977774294
p_ni:  0.022225706
Data Source:  BioPlex
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.817590717
p_ni:  0.182381689
p_wrong:  0.000027593
Data Source:  BioPlex
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.995
Data Source:  STRINGDB
ADK
Tchem
Family:  Kinase
Novelty:  0.00196435
Score:  0.992
Data Source:  STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.989
Data Source:  STRINGDB
HPRT1
Tchem
Family:  Enzyme
Novelty:  0.00032232
Score:  0.989
Data Source:  STRINGDB
GDA
Tbio
Family:  Enzyme
Novelty:  0.01846276
Score:  0.984
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.984
Data Source:  STRINGDB
AMPD3
Tchem
Family:  Enzyme
Novelty:  0.01230806
Score:  0.976
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.975
Data Source:  STRINGDB
Publication Statistics
PubMed Score  197.28

PubMed score by year
PubTator Score  553.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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