APRT
Adenine phosphoribosyltransferase
Protein Summary
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000378364
- ENSP00000367615
- ENSG00000198931
- ENST00000426324
- ENSP00000397007
- AMP
- APRTD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
biological process | 0.83 | ||
disease perturbation | 0.83 | ||
interacting protein | 0.82 | ||
histone modification site profile | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 215.4 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 318 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 215.4 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 318 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0