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Tbio
PFN1
Profilin-1

Protein Summary
Description
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225655
  • ENSP00000225655
  • ENSG00000108518

Symbol
  • ALS18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.97
hub protein
0.95
transcription factor
0.92
biological process
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.22   (req: < 5)
Gene RIFs: 93   (req: <= 3)
Antibodies: 399   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.22   (req: >= 5)
Gene RIFs: 93   (req: > 3)
Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
24.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
24.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
profilin 1
VGNC:9511
748477
Macaque
profilin 1
710753
Mouse
MGI:97549
18643
Rat
RGD:621825
64303
Dog
profilin 1
VGNC:53432
607397
Species
Name
OMA
EggNOG
Inparanoid
Chimp
profilin 1
Macaque
profilin 1
Mouse
Rat
Dog
profilin 1
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (213)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Developmental Biology
Reactome
Hemostasis
Reactome
PCP/CE pathway
Name
Explore in Pharos
Explore in Source
Axon guidance
Beta-catenin independent WNT signaling
Developmental Biology
Hemostasis
PCP/CE pathway
Gene Ontology Terms (34)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (153)
1 – 10 of 153
ACTB
Tbio
Novelty: 0.00006048
Score: 0.998
Data Source: STRINGDB
VASP
Tbio
Novelty: 0.00041984
Score: 0.988
Data Source: STRINGDB
ACTG1
Tbio
Novelty: 0.00086444
Score: 0.984
Data Source: STRINGDB
ACTA1
Tbio
Novelty: 0.00111813
Score: 0.98
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.977
Data Source: STRINGDB
FMNL1
Tbio
Novelty: 0.02318884
Score: 0.977
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.969
Data Source: STRINGDB
DAAM1
Tbio
Novelty: 0.02143008
Score: 0.963
Data Source: Reactome,STRINGDB
ENAH
Tbio
Novelty: 0.02329247
Score: 0.962
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  241.22

PubMed score by year
PubTator Score  153.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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