Protein Summary
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
- ENST00000225655
- ENSP00000225655
- ENSG00000108518
- ALS18
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
molecular function | 0.97 | ||
hub protein | 0.95 | ||
transcription factor | 0.92 | ||
biological process | 0.91 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 241.22 (req: < 5)
Gene RIFs: 93 (req: <= 3)
Antibodies: 399 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 241.22 (req: >= 5)
Gene RIFs: 93 (req: > 3)
Antibodies: 399 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 1 | 1 | 24.6 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 1 | 24.6 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | profilin 1 | VGNC:9511 | 748477 | |||||
Macaque | profilin 1 | 710753 | ||||||
Mouse | MGI:97549 | 18643 | ||||||
Rat | RGD:621825 | 64303 | ||||||
Dog | profilin 1 | VGNC:53432 | 607397 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | profilin 1 | |||||
Macaque | profilin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | profilin 1 | |||||
Protein Structure (12 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (213)
Reactome (14)
KEGG (4)
PathwayCommons (2)
WikiPathways (193)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Developmental Biology | ||||
Reactome | Hemostasis | ||||
Reactome | PCP/CE pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Beta-catenin independent WNT signaling | ||||
Developmental Biology | ||||
Hemostasis | ||||
PCP/CE pathway | ||||
Gene Ontology Terms (34)
Functions (8)
Components (10)
Processes (16)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (153)
1 – 10 of 153
ACTB
Novelty: 0.00006048
Score: 0.998
Data Source: STRINGDB
VASP
Novelty: 0.00041984
Score: 0.988
Data Source: STRINGDB
ACTG1
Novelty: 0.00086444
Score: 0.984
Data Source: STRINGDB
ACTA1
Novelty: 0.00111813
Score: 0.98
Data Source: STRINGDB
RHOC
Family: Enzyme
Novelty: 0.00262213
Score: 0.977
Data Source: STRINGDB
FMNL1
Novelty: 0.02318884
Score: 0.977
Data Source: STRINGDB
CDC42
Family: Enzyme
Novelty: 0.00032619
Score: 0.969
Data Source: STRINGDB
DAAM1
Novelty: 0.02143008
Score: 0.963
Data Source: Reactome,STRINGDB
ENAH
Novelty: 0.02329247
Score: 0.962
Data Source: STRINGDB
RHOA
Family: Enzyme
Novelty: 0.00022204
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score 241.22
PubMed score by year
PubTator Score 153.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword