Tbio PFN1 Profilin-1

Protein Summary

Description

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• P07737
• Q53Y44

Gene Name

• PFN1

Ensembl ID

• ENST00000225655
• ENSP00000225655
• ENSG00000108518

Symbol

• ALS18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
molecular function	0.97
hub protein	0.95
transcription factor	0.92
biological process	0.91

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.15   (req: < 5)

Gene RIFs: 93   (req: <= 3)

Antibodies: 399   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.15   (req: >= 5)

Gene RIFs: 93   (req: > 3)

Antibodies: 399   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (12)

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (213)

Reactome (14)

KEGG (4)

PathwayCommons (2)

WikiPathways (193)

Axon guidance (R-HSA-422475)

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1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Developmental Biology	1055 targets	R-HSA-1266738
Hemostasis	666 targets	R-HSA-109582
PCP/CE pathway	93 targets	R-HSA-4086400

Gene Ontology Terms (34)

Functions (8)

Components (10)

Processes (16)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
actin monomer binding	Inferred from Direct Assay (IDA)	UniProtKB
adenyl-nucleotide exchange factor activity	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
actin binding	Inferred from Physical Interaction (IPI)	UniProtKB
proline-rich region binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
Rho GTPase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (153)

Explore Interacting Targets

1 – 10 of 153

• See Interactions on String-DB

ACTB

Tbio

Novelty: 0.00027728

Score: 0.998

Data Source: STRINGDB

VASP

Tbio

Novelty: 0.00096602

Score: 0.988

Data Source: STRINGDB

ACTG1

Tbio

Novelty: 0.00111542

Score: 0.984

Data Source: STRINGDB

ACTA1

Tbio

Novelty: 0.00147233

Score: 0.98

Data Source: STRINGDB

RHOC

Tbio

Family: Enzyme

Novelty: 0.00407673

Score: 0.977

Data Source: STRINGDB

FMNL1

Tbio

Novelty: 0.03109564

Score: 0.977

Data Source: STRINGDB

CDC42

Tchem

Family: Enzyme

Novelty: 0.00039759

Score: 0.969

Data Source: STRINGDB

DAAM1

Tbio

Novelty: 0.03087963

Score: 0.963

Data Source: Reactome,STRINGDB

ENAH

Tbio

Novelty: 0.03560604

Score: 0.962

Data Source: STRINGDB

RHOA

Tbio

Family: Enzyme

Novelty: 0.0002729

Score: 0.959

Data Source: STRINGDB

Publication Statistics

PubMed Score  243.15

PubMed score by year

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PubTator Score  153.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Actin-binding
Amyotrophic lateral sclerosis
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Isopeptide bond

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
skeleton phenotype
vision/eye phenotype