Tclin CTSL Cathepsin L1

Protein Summary

Description

Important for the overall degradation of proteins in lysosomes. The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P07711
• Q6IAV1
• Q96QJ0

Gene Name

• CTSL

Ensembl ID

• ENST00000340342
• ENSP00000365061
• ENSG00000135047
• ENST00000343150
• ENSP00000345344

Symbol

• CTSL1
• MEP
• CATL
• CTSL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.99
cellular component	0.93
biological term	0.92
kinase perturbation	0.91
transcription factor perturbation	0.88

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1822.32   (req: < 5)

Gene RIFs: 152   (req: <= 3)

Antibodies: 528   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1822.32   (req: >= 5)

Gene RIFs: 152   (req: > 3)

Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1054

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

boceprevir

CTSLTclin Enzyme

pIC50 : 6.12

teicoplanin aglycone

CTSLTclin Enzyme

INHIBITOR pIC50 : 5.78

Active Ligands (1054)

Explore Active Ligands

1 – 10 of 1054

CHEMBL390474

CTSLTclin Enzyme

pIC50 : 7.66

CHEMBL230474

CTSLTclin Enzyme

pIC50 : 7.58

CHEMBL567341

CTSLTclin Enzyme

pIC50 : 6.93

L-trans-epoxysuccinylleucylamido(4-guanidino)-butane

CTSLTclin Enzyme

pKi : 7.52

CHEMBL567134

CTSLTclin Enzyme

pIC50 : 6.25

CHEMBL1288531

CTSLTclin Enzyme

pIC50 : 7.01

CHEMBL1288530

CTSLTclin Enzyme

pIC50 : 6.92

Pepstatin A

CTSLTclin Enzyme

pIC50 : 6.1

(R)-N-(Benzoyl)-S-(isobutyl)cysteinylsulfone-methylazaalanine-nitrile

CTSLTclin Enzyme

pKi : 7.82

relacatib

CTSLTclin Enzyme

pKi : 10.17

Protein-Protein Interactions (163)

Explore Interacting Targets

1 – 10 of 163

• See Interactions on String-DB

CTSL3P

Tdark

Family:  Enzyme

p_int:  0.999999126

p_wrong:  8.73e-7

Data Source:  BioPlex

CSTA

Tbio

Novelty:  0.00453121

p_int:  0.999940537

p_ni:  0.00005939

p_wrong:  7.3e-8

Score:  0.952

Data Source:  BioPlex,STRINGDB

CST1

Tbio

Novelty:  0.02399609

p_int:  0.999300943

p_ni:  0.000699057

Score:  0.79

Data Source:  BioPlex,STRINGDB

CCDC88A

Tbio

Novelty:  0.01077253

p_int:  0.981813499

p_ni:  0.0181865

p_wrong:  1e-9

Score:  0.2

Data Source:  BioPlex,STRINGDB

CST7

Tbio

Novelty:  0.03651959

p_int:  0.981553926

p_ni:  0.018446074

Score:  0.746

Data Source:  BioPlex,STRINGDB

CTSK

Tchem

Family:  Enzyme

Novelty:  0.0007707

p_int:  0.971383533

p_ni:  0.028215006

p_wrong:  0.000401462

Score:  0.841

Data Source:  BioPlex,STRINGDB

CTSV

Tchem

Family:  Enzyme

Novelty:  0.00916301

p_int:  0.958589335

p_ni:  0.041410647

p_wrong:  1.8e-8

Score:  0.703

Data Source:  BioPlex,STRINGDB

CLTCL1

Tbio

Novelty:  0.05667807

p_int:  0.935909066

p_ni:  0.064090934

Score:  0.273

Data Source:  BioPlex,STRINGDB

CTSH

Tchem

Family:  Enzyme

Novelty:  0.00336694

p_int:  0.935815261

p_ni:  0.064184281

p_wrong:  4.58e-7

Score:  0.62

Data Source:  BioPlex,STRINGDB

CD74

Tchem

Novelty:  0.00281228

Score:  0.991

Data Source:  STRINGDB

Pathways (34)

Reactome (19)

KEGG (8)

WikiPathways (7)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 5 of 19

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Collagen degradation	40 targets	R-HSA-1442490

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Assembly of collagen fibrils and other multimeric structures	57 targets	R-HSA-2022090
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Collagen degradation	40 targets	R-HSA-1442490

Gene Ontology Terms (25)

Functions (8)

Components (7)

Processes (10)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
collagen binding	Inferred from Direct Assay (IDA)	BHF-UCL
cysteine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
cysteine-type peptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
histone binding	Inferred from Direct Assay (IDA)	BHF-UCL
fibronectin binding	Inferred from Physical Interaction (IPI)	BHF-UCL
proteoglycan binding	Inferred from Physical Interaction (IPI)	BHF-UCL
serpin family protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cathepsin L1 measurement	EFO_0010619	1	1	1		82.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cathepsin L1 measurement	EFO_0010619	1		82.9

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UniProt Keyword Find Similar Targets

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3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Protease
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
cathepsin L1 measurement

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cathepsin L	VGNC:4666	737449
Macaque	cathepsin L		694569
Platypus	cathepsin L1-like		100093403

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cathepsin L
Macaque	cathepsin L
Platypus	cathepsin L1-like

Publication Statistics

PubMed Score 1822.32

PubMed score by year

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PubTator Score 811.41

PubTator score by year

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