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Tclin
CTSL
Cathepsin L1

Protein Summary
Description
Important for the overall degradation of proteins in lysosomes. The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340342
  • ENSP00000365061
  • ENSG00000135047
  • ENST00000343150
  • ENSP00000345344

Symbol
  • CTSL1
  • MEP
  • CATL
  • CTSL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.99
cellular component
0.93
biological term
0.92
kinase perturbation
0.91
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2605   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 528   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2605   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 528   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 863
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (36)
1 – 5 of 36
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Assembly of collagen fibrils and other multimeric structures
Class I MHC mediated antigen processing & presentation
Collagen degradation
Gene Ontology Terms (25)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (163)
1 – 10 of 163
CTSL3P
Tdark
Family: Enzyme
p_int: 0.999999126
p_wrong: 8.73e-7
Data Source: BioPlex
CSTA
Tbio
Novelty: 0.00454682
p_int: 0.999940537
p_ni: 0.00005939
p_wrong: 7.3e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
CST1
Tbio
Novelty: 0.02481888
p_int: 0.999300943
p_ni: 0.000699057
Score: 0.79
Data Source: BioPlex,STRINGDB
CCDC88A
Tbio
Novelty: 0.01149743
p_int: 0.981813499
p_ni: 0.0181865
p_wrong: 1e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
CST7
Tbio
Novelty: 0.04017757
p_int: 0.981553926
p_ni: 0.018446074
Score: 0.746
Data Source: BioPlex,STRINGDB
CTSK
Tchem
Family: Enzyme
Novelty: 0.00091225
p_int: 0.971383533
p_ni: 0.028215006
p_wrong: 0.000401462
Score: 0.841
Data Source: BioPlex,STRINGDB
CTSV
Tchem
Family: Enzyme
Novelty: 0.01731555
p_int: 0.958589335
p_ni: 0.041410647
p_wrong: 1.8e-8
Score: 0.703
Data Source: BioPlex,STRINGDB
CLTCL1
Tbio
Novelty: 0.05165674
p_int: 0.935909066
p_ni: 0.064090934
Score: 0.273
Data Source: BioPlex,STRINGDB
CTSH
Tchem
Family: Enzyme
Novelty: 0.00380318
p_int: 0.935815261
p_ni: 0.064184281
p_wrong: 4.58e-7
Score: 0.62
Data Source: BioPlex,STRINGDB
CD74
Tchem
Novelty: 0.00337387
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  2605.00

PubMed score by year
PubTator Score  811.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGK
1-70
HSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWA
70-140
FSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEES
140-210
CKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLV
210-280
VGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
280-333
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV