Protein Classes
Protein Summary
Important for the overall degradation of proteins in lysosomes. The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
- ENST00000340342
- ENSP00000365061
- ENSG00000135047
- ENST00000343150
- ENSP00000345344
- CTSL1
- MEP
- CATL
- CTSL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.99 | ||
cellular component | 0.93 | ||
biological term | 0.92 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.88 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2605 (req: < 5)
Gene RIFs: 152 (req: <= 3)
Antibodies: 528 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2605 (req: >= 5)
Gene RIFs: 152 (req: > 3)
Antibodies: 528 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 863
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (863)
1 – 10 of 863
Protein Data Bank (36)
1 – 5 of 36
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (34)
Reactome (19)
KEGG (8)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 19
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Collagen degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Assembly of collagen fibrils and other multimeric structures | ||||
Class I MHC mediated antigen processing & presentation | ||||
Collagen degradation | ||||
Gene Ontology Terms (25)
Functions (8)
Components (7)
Processes (10)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (163)
1 – 10 of 163
CTSL3P
Family: Enzyme
p_int: 0.999999126
p_wrong: 8.73e-7
Data Source: BioPlex
CSTA
Novelty: 0.00454682
p_int: 0.999940537
p_ni: 0.00005939
p_wrong: 7.3e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
CST1
Novelty: 0.02481888
p_int: 0.999300943
p_ni: 0.000699057
Score: 0.79
Data Source: BioPlex,STRINGDB
CCDC88A
Novelty: 0.01149743
p_int: 0.981813499
p_ni: 0.0181865
p_wrong: 1e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
CST7
Novelty: 0.04017757
p_int: 0.981553926
p_ni: 0.018446074
Score: 0.746
Data Source: BioPlex,STRINGDB
CTSK
Family: Enzyme
Novelty: 0.00091225
p_int: 0.971383533
p_ni: 0.028215006
p_wrong: 0.000401462
Score: 0.841
Data Source: BioPlex,STRINGDB
CTSV
Family: Enzyme
Novelty: 0.01731555
p_int: 0.958589335
p_ni: 0.041410647
p_wrong: 1.8e-8
Score: 0.703
Data Source: BioPlex,STRINGDB
CLTCL1
Novelty: 0.05165674
p_int: 0.935909066
p_ni: 0.064090934
Score: 0.273
Data Source: BioPlex,STRINGDB
CTSH
Family: Enzyme
Novelty: 0.00380318
p_int: 0.935815261
p_ni: 0.064184281
p_wrong: 4.58e-7
Score: 0.62
Data Source: BioPlex,STRINGDB
CD74
Novelty: 0.00337387
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score 2605.00
PubMed score by year
PubTator Score 811.41
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGK
1-70
HSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWA
70-140
FSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEES
140-210
CKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLV
210-280
VGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
280-333
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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