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Tbio
PSAP
Prosaposin

Protein Classes
Protein Summary
Description
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic p ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.99
disease perturbation
0.93
protein domain
0.92
PubMedID
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.47   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 236.47   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glycosphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Glycosphingolipid metabolism
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (329)
1 – 10 of 329
GBA
Tclin
Family: Enzyme
Novelty: 0.0004484
Score: 0.972
Data Source: Reactome,STRINGDB
GPR37L1
Tbio
Family: GPCR
Novelty: 0.11748252
Score: 0.963
Data Source: Reactome,STRINGDB
GPR37
Tbio
Family: GPCR
Novelty: 0.02427642
Score: 0.951
Data Source: Reactome,STRINGDB
DDOST
Tchem
Family: Enzyme
Novelty: 0.02436696
Score: 0.942
Data Source: STRINGDB
LAMP1
Tbio
Novelty: 0.00104159
Score: 0.941
Data Source: STRINGDB
SURF4
Tbio
Novelty: 0.04858197
Score: 0.938
Data Source: STRINGDB
LAMP2
Tbio
Novelty: 0.00223951
Score: 0.925
Data Source: STRINGDB
MAGT1
Tbio
Novelty: 0.02562036
Score: 0.924
Data Source: STRINGDB
MANBA
Tchem
Family: Enzyme
Novelty: 0.00878537
Score: 0.921
Data Source: STRINGDB
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00034716
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  236.47

PubMed score by year
PubTator Score  190.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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