Tbio DCN Decorin

Protein Summary

Description

May affect the rate of fibrils formation. This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P07585
• Q9P0Z0
• Q9P0Z1
• Q9Y5N8
• Q9Y5N9

Gene Name

• DCN

Ensembl ID

• ENST00000052754
• ENSP00000052754
• ENSG00000011465
• ENST00000393155
• ENSP00000376862
• ENST00000420120
• ENSP00000413723
• ENST00000425043
• ENSP00000401021
• ENST00000441303
• ENSP00000399815
• ENST00000456569
• ENSP00000398514
• ENST00000547568
• ENSP00000447674
• ENST00000552962
• ENSP00000447654

Symbol

• SLRR1B
• CSCD
• PG40
• PGII
• PGS2
• DSPG2
• SLRR1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.95
PubMedID	0.94
disease perturbation	0.93
small molecule perturbation	0.92
kinase perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1551.3   (req: < 5)

Gene RIFs: 188   (req: <= 3)

Antibodies: 582   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1551.3   (req: >= 5)

Gene RIFs: 188   (req: > 3)

Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0