Tbio DCN Decorin

Protein Summary

Description

May affect the rate of fibrils formation. This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P07585
• Q9P0Z0
• Q9P0Z1
• Q9Y5N8
• Q9Y5N9

Gene Name

• DCN

Ensembl ID

• ENST00000052754
• ENSP00000052754
• ENSG00000011465
• ENST00000393155
• ENSP00000376862
• ENST00000420120
• ENSP00000413723
• ENST00000425043
• ENSP00000401021
• ENST00000441303
• ENSP00000399815
• ENST00000456569
• ENSP00000398514
• ENST00000547568
• ENSP00000447674
• ENST00000552962
• ENSP00000447654

Symbol

• SLRR1B
• CSCD
• PG40
• PGII
• PGS2
• DSPG2
• SLRR1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.95
PubMedID	0.94
disease perturbation	0.93
small molecule perturbation	0.92
kinase perturbation	0.88

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1447.64   (req: < 5)

Gene RIFs: 155   (req: <= 3)

Antibodies: 582   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1447.64   (req: >= 5)

Gene RIFs: 155   (req: > 3)

Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	2	1	0	3	15.6
intraocular pressure measurement	EFO_0004695	1	1	1		5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
central corneal thickness	EFO_0005213	0	3	15.6
intraocular pressure measurement	EFO_0004695	1		5

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	decorin	VGNC:5353	452120
Macaque	decorin		709933
Mouse	decorin	MGI:94872	13179
Rat	decorin	RGD:61895	29139
Dog	decorin	VGNC:54200	403904

Species	Name	OMA	EggNOG	Inparanoid
Chimp	decorin
Macaque	decorin
Mouse	decorin
Rat	decorin
Dog	decorin

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P07585-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)

Reactome (21)

KEGG (2)

PathwayCommons (2)

WikiPathways (2)

A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

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Find Similar Targets

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5

1 – 5 of 21

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
Reactome	CS/DS degradation	14 targets	R-HSA-2024101
Reactome	Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Name	Explore in Pharos	Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis	26 targets	R-HSA-1971475
CS/DS degradation	14 targets	R-HSA-2024101
Chondroitin sulfate biosynthesis	20 targets	R-HSA-2022870
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Defective B3GALT6 causes EDSP2 and SEMDJL1	20 targets	R-HSA-4420332

Gene Ontology Terms (34)

Functions (6)

Components (6)

Processes (22)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
extracellular matrix structural constituent conferring compression resistance	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
collagen binding	Inferred from Electronic Annotation (IEA)	Ensembl
extracellular matrix binding	Inferred from Electronic Annotation (IEA)	Ensembl
glycosaminoglycan binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein N-terminus binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (234)

Explore Interacting Targets

1 – 10 of 234

• See Interactions on String-DB

CHSY1

Tbio

Family:  Enzyme

Novelty:  0.03515909

p_int:  0.999984236

p_ni:  0.000015764

Score:  0.939

Data Source:  BioPlex,STRINGDB

KLHL17

Tdark

Novelty:  0.22103723

p_int:  0.995539871

p_ni:  0.000002171

p_wrong:  0.004457958

Score:  0.485

Data Source:  BioPlex,STRINGDB

MMP2

Tchem

Family:  Enzyme

Novelty:  0.00012762

Score:  0.993

Data Source:  Reactome,STRINGDB

VCAN

Tbio

Novelty:  0.00110986

Score:  0.985

Data Source:  STRINGDB

HSPG2

Tbio

Family:  Enzyme

Novelty:  0.00159541

Score:  0.975

Data Source:  STRINGDB

COL1A2

Tbio

Novelty:  0.00048334

Score:  0.974

Data Source:  STRINGDB

MMP3

Tchem

Novelty:  0.00041675

Score:  0.973

Data Source:  Reactome,STRINGDB

TGFB1

Tbio

Novelty:  0.0001299

Score:  0.969

Data Source:  Reactome,STRINGDB

EGFR

Tclin

Family:  Kinase

Novelty:  0.00007274

Score:  0.968

Data Source:  STRINGDB

COL1A1

Tbio

Novelty:  0.00063584

Score:  0.966

Data Source:  STRINGDB

Publication Statistics

PubMed Score  1447.64

PubMed score by year

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PubTator Score  465.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Corneal dystrophy
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Leucine-rich repeat
Polymorphism
Proteoglycan

GWAS Trait Find Similar Targets

No Header	No Header
central corneal thickness
intraocular pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
immune system phenotype
integument phenotype
muscle phenotype
renal/urinary system phenotype
reproductive system phenotype