Protein Summary
May affect the rate of fibrils formation. This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
- ENST00000052754
- ENSP00000052754
- ENSG00000011465
- ENST00000393155
- ENSP00000376862
- ENST00000420120
- ENSP00000413723
- ENST00000425043
- ENSP00000401021
- ENST00000441303
- ENSP00000399815
- ENST00000456569
- ENSP00000398514
- ENST00000547568
- ENSP00000447674
- ENST00000552962
- ENSP00000447654
- SLRR1B
- CSCD
- PG40
- PGII
- PGS2
- DSPG2
- SLRR1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.95 | ||
PubMedID | 0.94 | ||
disease perturbation | 0.93 | ||
small molecule perturbation | 0.92 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1447.64 (req: < 5)
Gene RIFs: 155 (req: <= 3)
Antibodies: 582 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1447.64 (req: >= 5)
Gene RIFs: 155 (req: > 3)
Antibodies: 582 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (234)
CHSY1
Family: Enzyme
Novelty: 0.03515909
p_int: 0.999984236
p_ni: 0.000015764
Score: 0.939
Data Source: BioPlex,STRINGDB
KLHL17
Novelty: 0.22103723
p_int: 0.995539871
p_ni: 0.000002171
p_wrong: 0.004457958
Score: 0.485
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Downstream (4)
1 – 4 of 4
Pathways (27)
Reactome (21)
KEGG (2)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | A tetrasaccharide linker sequence is required for GAG synthesis | ||||
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate biosynthesis | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
A tetrasaccharide linker sequence is required for GAG synthesis | ||||
CS/DS degradation | ||||
Chondroitin sulfate biosynthesis | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Defective B3GALT6 causes EDSP2 and SEMDJL1 | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (6)
Components (6)
Processes (22)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
central corneal thickness | 2 | 1 | 0 | 3 | 15.6 | ||||
intraocular pressure measurement | 1 | 1 | 1 | 5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
central corneal thickness | 0 | 3 | 15.6 | ||||
intraocular pressure measurement | 1 | 5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | decorin | VGNC:5353 | 452120 | |||||
Macaque | decorin | 709933 | ||||||
Mouse | MGI:94872 | 13179 | ||||||
Rat | RGD:61895 | 29139 | ||||||
Dog | decorin | VGNC:54200 | 403904 | |||||
Publication Statistics
PubMed Score 1447.64
PubMed score by year
PubTator Score 465.17
PubTator score by year
Related Publications
Text Mined References (217)
GeneRif Annotations (155)
Items per page:
0 of 0
PMID | Year | Title |
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