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Tbio
DCN
Decorin

Protein Summary
Description
May affect the rate of fibrils formation. This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000052754
  • ENSP00000052754
  • ENSG00000011465
  • ENST00000393155
  • ENSP00000376862
  • ENST00000420120
  • ENSP00000413723
  • ENST00000425043
  • ENSP00000401021
  • ENST00000441303
  • ENSP00000399815
  • ENST00000456569
  • ENSP00000398514
  • ENST00000547568
  • ENSP00000447674
  • ENST00000552962
  • ENSP00000447654

Symbol
  • SLRR1B
  • CSCD
  • PG40
  • PGII
  • PGS2
  • DSPG2
  • SLRR1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
PubMedID
0.94
disease perturbation
0.93
small molecule perturbation
0.92
kinase perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1447.64   (req: < 5)
Gene RIFs: 155   (req: <= 3)
Antibodies: 582   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1447.64   (req: >= 5)
Gene RIFs: 155   (req: > 3)
Antibodies: 582   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
1
0
3
15.6
intraocular pressure measurement
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3
15.6
intraocular pressure measurement
1
5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
decorin
VGNC:5353
452120
Macaque
decorin
709933
Mouse
MGI:94872
13179
Rat
RGD:61895
29139
Dog
decorin
VGNC:54200
403904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
decorin
Macaque
decorin
Mouse
Rat
Dog
decorin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P07585-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (27)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (34)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (234)
1 – 10 of 234
CHSY1
Tbio
Family:  Enzyme
Novelty:  0.03515909
p_int:  0.999984236
p_ni:  0.000015764
Score:  0.939
Data Source:  BioPlex,STRINGDB
KLHL17
Tdark
Novelty:  0.22103723
p_int:  0.995539871
p_ni:  0.000002171
p_wrong:  0.004457958
Score:  0.485
Data Source:  BioPlex,STRINGDB
MMP2
Tchem
Family:  Enzyme
Novelty:  0.00012762
Score:  0.993
Data Source:  Reactome,STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.985
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.975
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.974
Data Source:  STRINGDB
MMP3
Tchem
Novelty:  0.00041675
Score:  0.973
Data Source:  Reactome,STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.969
Data Source:  Reactome,STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.968
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1447.64

PubMed score by year
PubTator Score  465.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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