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Tclin
CHRNG
Acetylcholine receptor subunit gamma

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389492
  • ENSP00000374143
  • ENSG00000196811
  • ENST00000389494
  • ENSP00000374145

Symbol
  • ACHRG
  • ACHRG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
cell type or tissue
0.83
gene perturbation
0.76
phenotype
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.87   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.87   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
ACTL6B
Tbio
Novelty:  0.05740204
p_int:  0.931400868
p_ni:  0.06541401
p_wrong:  0.003185121
Score:  0.507
Data Source:  BioPlex,STRINGDB
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
Score:  0.979
Data Source:  STRINGDB
RAPSN
Tbio
Novelty:  0.00565077
Score:  0.969
Data Source:  STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
Score:  0.963
Data Source:  STRINGDB
MUSK
Tchem
Family:  Kinase
Novelty:  0.00151518
Score:  0.956
Data Source:  STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.938
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.91
Data Source:  STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.91
Data Source:  Reactome,STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.909
Data Source:  Reactome,STRINGDB
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.908
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly sodium permeable acetylcholine nicotinic receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Postsynaptic nicotinic acetylcholine receptors
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly sodium permeable acetylcholine nicotinic receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Postsynaptic nicotinic acetylcholine receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
5
6
12.7
97.6
Myopia
3
2
0
1.3
86.9
corneal topography
2
1
2
83.9
age at onset
1
1
0
12.7
81.9
bilirubin measurement
1
2
2
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
6
12.7
97.6
Myopia
0
1.3
86.9
corneal topography
2
83.9
age at onset
0
12.7
81.9
bilirubin measurement
2
73.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic gamma subunit
VGNC:138
470680
Macaque
cholinergic receptor nicotinic gamma subunit
713418
Mouse
MGI:87895
11449
Dog
cholinergic receptor nicotinic gamma subunit
VGNC:39248
486163
Horse
cholinergic receptor nicotinic gamma subunit
VGNC:16532
100057215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic gamma subunit
Macaque
cholinergic receptor nicotinic gamma subunit
Mouse
Dog
cholinergic receptor nicotinic gamma subunit
Horse
cholinergic receptor nicotinic gamma subunit
Publication Statistics
PubMed Score 27.87
PubMed score by year
PubTator Score 16.46
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title