Tbio GRP Gastrin-releasing peptide

Protein Summary

Description

Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P07492
• P07491
• P81553
• Q14454
• Q53YA0
• Q9BSY7
• GRP

Gene Name

• GRP

Ensembl ID

• ENST00000256857
• ENSP00000256857
• ENSG00000134443
• ENST00000420468
• ENSP00000389696
• ENST00000529320
• ENSP00000434101

Symbol

• BN
• GRP-10
• proGRP
• preproGRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.82
PubMedID	0.8
disease perturbation	0.62
biological term	0.59
cell type or tissue	0.5

Protein Classes

DTO Classes

Gastrin-releasing Peptide Receptor / Gastrin-releasing Peptide

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3258.67   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3258.67   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0