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Tbio
GRP
Gastrin-releasing peptide

Protein Classes
Protein Summary
Description
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256857
  • ENSP00000256857
  • ENSG00000134443
  • ENST00000420468
  • ENSP00000389696
  • ENST00000529320
  • ENSP00000434101

Symbol
  • BN
  • GRP-10
  • proGRP
  • preproGRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
PubMedID
0.8
disease perturbation
0.62
biological term
0.59
cell type or tissue
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3145.29   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3145.29   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Incretin synthesis, secretion, and inactivation
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Incretin synthesis, secretion, and inactivation
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Non-traceable Author Statement (NAS)
ProtInc
Protein-Protein Interactions (262)
1 – 10 of 262
SUFU
Tbio
Novelty: 0.00475249
p_int: 0.999997631
p_ni: 0.000002369
Data Source: BioPlex
DALRD3
Tdark
Novelty: 0.5378666
p_int: 0.998826424
p_ni: 0.000001164
p_wrong: 0.001172412
Data Source: BioPlex
CDKN2C
Tbio
Family: Enzyme
Novelty: 0.00806886
p_int: 0.998634875
p_ni: 0.001152678
p_wrong: 0.000212448
Data Source: BioPlex
CETN3
Tbio
Novelty: 0.00705513
p_int: 0.994634802
p_ni: 0.005364653
p_wrong: 5.45e-7
Data Source: BioPlex
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.926583351
p_ni: 0.072413701
p_wrong: 0.001002948
Data Source: BioPlex
ADO
Tbio
Family: Enzyme
Novelty: 0.04529593
p_int: 0.891545486
p_ni: 0.000665876
p_wrong: 0.107788638
Data Source: BioPlex
THNSL1
Tdark
Family: Enzyme
Novelty: 1.98275016
p_int: 0.852143651
p_ni: 0.147856229
p_wrong: 1.2e-7
Data Source: BioPlex
DCTN3
Tbio
Novelty: 0.14551388
p_int: 0.845691428
p_ni: 0.154290353
p_wrong: 0.000018219
Data Source: BioPlex
GNB1L
Tbio
Novelty: 0.03388865
p_int: 0.75864951
p_ni: 0.241350475
p_wrong: 1.6e-8
Data Source: BioPlex
UGDH
Tbio
Family: Enzyme
Novelty: 0.00284931
p_int: 0.758101302
p_ni: 0.241898698
Data Source: BioPlex
Publication Statistics
PubMed Score  3145.29

PubMed score by year
PubTator Score  1618.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer