Tchem PRSS2 Trypsin-2

Protein Summary

Description

In the ileum, may be involved in defensin processing, including DEFA5. This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P07478

Gene Name

• PRSS2

Ensembl ID

• ENST00000539842
• ENSP00000488338
• ENSG00000275896
• ENST00000632112
• ENSP00000487952
• ENSG00000282049

Symbol

• TRY2
• TRYP2
• TRY2
• TRY8
• TRYP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
protein domain	0.58
tissue	0.54
molecular function	0.53
drug	0.51

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Trypsin-2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Trypsin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.49   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.49   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

dabigatran etexilate

PRSS2Tchem Enzyme

INHIBITOR pKi : 8.35

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (145)

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1 – 10 of 145

• See Interactions on String-DB

TUBB1

Tclin

Novelty:  0.02806117

p_int:  0.999988292

p_ni:  0.000011707

Data Source:  BioPlex

SLC35A2

Tbio

Family:  Transporter

Novelty:  0.00072521

p_int:  0.997647192

p_ni:  0.002326453

p_wrong:  0.000026354

Score:  0.629

Data Source:  BioPlex,STRINGDB

GSTT1

Tbio

Family:  Enzyme

p_int:  0.99035641

p_ni:  0.009629669

p_wrong:  0.00001392

Data Source:  BioPlex

CIDEC

Tbio

Novelty:  0.01081754

p_int:  0.971629401

p_ni:  0.006706257

p_wrong:  0.021664342

Score:  0.269

Data Source:  BioPlex,STRINGDB

ITGA4

Tclin

Novelty:  0.00197607

p_int:  0.957084011

p_ni:  0.042682596

p_wrong:  0.000233392

Score:  0.178

Data Source:  BioPlex,STRINGDB

TMEM252

Tdark

Novelty:  0.5615322

p_int:  0.944928224

p_ni:  0.025877531

p_wrong:  0.029194245

Score:  0.622

Data Source:  BioPlex,STRINGDB

GDF11

Tclin

Novelty:  0.00585981

p_int:  0.942690956

p_ni:  0.046441541

p_wrong:  0.010867503

Score:  0.166

Data Source:  BioPlex,STRINGDB

HSPA5

Tchem

Novelty:  0.00043424

p_int:  0.907160838

p_ni:  0.092839162

Score:  0.224

Data Source:  BioPlex,STRINGDB

FN1

Tchem

Novelty:  0.00003647

p_int:  0.806212727

p_ni:  0.193787272

p_wrong:  1e-9

Score:  0.326

Data Source:  BioPlex,STRINGDB

TUBB3

Tclin

Novelty:  0.00195963

p_int:  0.791927538

p_ni:  0.208072462

Data Source:  BioPlex

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

F2R

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  1

1: Neuroactive ligand-receptor interaction

Pathways (14)

Reactome (10)

KEGG (4)

Activation of Matrix Metalloproteinases (R-HSA-1592389)

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5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Reactome	Alpha-defensins	9 targets	R-HSA-1462054
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Defensins	45 targets	R-HSA-1461973

Name	Explore in Pharos	Explore in Source
Activation of Matrix Metalloproteinases	33 targets	R-HSA-1592389
Alpha-defensins	9 targets	R-HSA-1462054
Antimicrobial peptides	89 targets	R-HSA-6803157
Collagen degradation	40 targets	R-HSA-1442490
Defensins	45 targets	R-HSA-1461973

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (4)

Components (4)

Processes (8)

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1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
serine-type endopeptidase activity	Inferred from Direct Assay (IDA)	UniProtKB
metalloendopeptidase activity	Traceable Author Statement (TAS)	Reactome
serine-type peptidase activity	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alcoholic pancreatitis	EFO_1002013	ENSG00000275896	1	33	0	1.7	97.9
alcoholic pancreatitis	EFO_1002013	ENSG00000282049	1	33	0	1.7	97.9

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alcoholic pancreatitis	EFO_1002013	0	1.7	97.9
alcoholic pancreatitis	EFO_1002013	0	1.7	97.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Complete proteome
Digestion
Direct protein sequencing
Disulfide bond
Hydrolase
Metal-binding
Polymorphism
Protease
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alcoholic pancreatitis

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs

No orthologs found

Publication Statistics

PubMed Score 131.49

PubMed score by year

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PubTator Score 132.23

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (32)

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PMID	Year	Title