Protein Summary
In the ileum, may be involved in defensin processing, including DEFA5. This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
- ENST00000539842
- ENSP00000488338
- ENSG00000275896
- ENST00000632112
- ENSP00000487952
- ENSG00000282049
- TRY2
- TRYP2
- TRY2
- TRY8
- TRYP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
protein domain | 0.58 | ||
tissue | 0.54 | ||
molecular function | 0.53 | ||
drug | 0.51 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.49 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.49 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
Protein-Protein Interactions (145)
1 – 10 of 145
TUBB1
Novelty: 0.02806117
p_int: 0.999988292
p_ni: 0.000011707
Data Source: BioPlex
SLC35A2
Family: Transporter
Novelty: 0.00072521
p_int: 0.997647192
p_ni: 0.002326453
p_wrong: 0.000026354
Score: 0.629
Data Source: BioPlex,STRINGDB
GSTT1
Family: Enzyme
p_int: 0.99035641
p_ni: 0.009629669
p_wrong: 0.00001392
Data Source: BioPlex
CIDEC
Novelty: 0.01081754
p_int: 0.971629401
p_ni: 0.006706257
p_wrong: 0.021664342
Score: 0.269
Data Source: BioPlex,STRINGDB
ITGA4
Novelty: 0.00197607
p_int: 0.957084011
p_ni: 0.042682596
p_wrong: 0.000233392
Score: 0.178
Data Source: BioPlex,STRINGDB
TMEM252
Novelty: 0.5615322
p_int: 0.944928224
p_ni: 0.025877531
p_wrong: 0.029194245
Score: 0.622
Data Source: BioPlex,STRINGDB
GDF11
Novelty: 0.00585981
p_int: 0.942690956
p_ni: 0.046441541
p_wrong: 0.010867503
Score: 0.166
Data Source: BioPlex,STRINGDB
HSPA5
Novelty: 0.00043424
p_int: 0.907160838
p_ni: 0.092839162
Score: 0.224
Data Source: BioPlex,STRINGDB
FN1
Novelty: 0.00003647
p_int: 0.806212727
p_ni: 0.193787272
p_wrong: 1e-9
Score: 0.326
Data Source: BioPlex,STRINGDB
TUBB3
Novelty: 0.00195963
p_int: 0.791927538
p_ni: 0.208072462
Data Source: BioPlex
Pathways (14)
Reactome (10)
KEGG (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Alpha-defensins | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Collagen degradation | ||||
Reactome | Defensins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Alpha-defensins | ||||
Antimicrobial peptides | ||||
Collagen degradation | ||||
Defensins | ||||
Gene Ontology Terms (16)
Functions (4)
Components (4)
Processes (8)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
1 | 33 | 0 | 1.7 | 97.9 | ||||||
1 | 33 | 0 | 1.7 | 97.9 | ||||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.7 | 97.9 | |||||
0 | 1.7 | 97.9 | |||||
Find similar targets by:
UniProt Keyword
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Publication Statistics
PubMed Score 131.49
PubMed score by year
PubTator Score 132.23
PubTator score by year