Tchem PRSS2 Trypsin-2

Protein Summary

Description

In the ileum, may be involved in defensin processing, including DEFA5. This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]

Uniprot Accession IDs

• P07478

Gene Name

• PRSS2

Ensembl ID

• ENST00000539842
• ENSP00000488338
• ENSG00000275896
• ENST00000632112
• ENSP00000487952
• ENSG00000282049

Symbol

• TRY2
• TRYP2
• TRY2
• TRY8
• TRYP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
protein domain	0.58
tissue	0.54
molecular function	0.53
drug	0.51

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Trypsin-2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Trypsin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.36   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.36   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1