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Tchem
PRSS2
Trypsin-2

Protein Summary
Description
In the ileum, may be involved in defensin processing, including DEFA5. This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000539842
  • ENSP00000488338
  • ENSG00000275896
  • ENST00000632112
  • ENSP00000487952
  • ENSG00000282049

Symbol
  • TRY2
  • TRYP2
  • TRY2
  • TRY8
  • TRYP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
protein domain
0.58
tissue
0.54
molecular function
0.53
drug
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.83   (req: < 5)
View Publications
Gene RIFs: 32   (req: <= 3)
View Gene RIFs
Antibodies: 134   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.83   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Explore Approved Drugs
Pathways (14)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
33 targets
R-HSA-1592389
Reactome
Alpha-defensins
9 targets
R-HSA-1462054
Reactome
Antimicrobial peptides
89 targets
R-HSA-6803157
Reactome
Collagen degradation
40 targets
R-HSA-1442490
Reactome
Defensins
45 targets
R-HSA-1461973
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
33 targets
R-HSA-1592389
Alpha-defensins
9 targets
R-HSA-1462054
Antimicrobial peptides
89 targets
R-HSA-6803157
Collagen degradation
40 targets
R-HSA-1442490
Defensins
45 targets
R-HSA-1461973
Protein-Protein Interactions (145)
1 – 10 of 145
TUBB1
Tclin
Novelty: 0.05351568
p_int: 0.999988292
p_ni: 0.000011707
Data Source: BioPlex
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00095598
p_int: 0.997647192
p_ni: 0.002326453
p_wrong: 0.000026354
Score: 0.629
Data Source: BioPlex,STRINGDB
GSTT1
Tbio
Family: Enzyme
p_int: 0.99035641
p_ni: 0.009629669
p_wrong: 0.00001392
Data Source: BioPlex
CIDEC
Tbio
Novelty: 0.01333028
p_int: 0.971629401
p_ni: 0.006706257
p_wrong: 0.021664342
Score: 0.269
Data Source: BioPlex,STRINGDB
ITGA4
Tclin
Novelty: 0.00307318
p_int: 0.957084011
p_ni: 0.042682596
p_wrong: 0.000233392
Score: 0.178
Data Source: BioPlex,STRINGDB
TMEM252
Tdark
Novelty: 0.83193277
p_int: 0.944928224
p_ni: 0.025877531
p_wrong: 0.029194245
Score: 0.622
Data Source: BioPlex,STRINGDB
GDF11
Tclin
Novelty: 0.00702501
p_int: 0.942690956
p_ni: 0.046441541
p_wrong: 0.010867503
Score: 0.166
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00051387
p_int: 0.907160838
p_ni: 0.092839162
Score: 0.224
Data Source: BioPlex,STRINGDB
FN1
Tchem
Novelty: 0.0000437
p_int: 0.806212727
p_ni: 0.193787272
p_wrong: 1e-9
Score: 0.326
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00281462
p_int: 0.791927538
p_ni: 0.208072462
Data Source: BioPlex
Publication Statistics
PubMed Score  138.83

PubMed score by year
PubTator Score  132.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer