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Tclin
PRSS1
Trypsin-1

Protein Summary
Description
Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates. This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311737
  • ENSP00000308720
  • ENSG00000204983
  • ENST00000616256
  • ENSP00000479217
  • ENSG00000274247

Symbol
  • TRP1
  • TRY1
  • TRYP1
  • TRP1
  • TRY1
  • TRY4
  • TRYP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.76
cell type or tissue
0.73
cell line
0.69
disease
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 614.78   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 614.78   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 859
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
nafamostat
chemical structure image
camostat
chemical structure image
Active Ligands (859)
1 – 10 of 859
CHEMBL290376,CHEMBL607008
chemical structure image
CHEMBL19902,CHEMBL539053
chemical structure image
CHEMBL46618
chemical structure image
CHEMBL37251,CHEMBL152854
chemical structure image
CHEMBL51173
chemical structure image
CHEMBL279628,CHEMBL139063
chemical structure image
CHEMBL96433
chemical structure image
CHEMBL176140,CHEMBL559015
chemical structure image
CHEMBL3667913
chemical structure image
CHEMBL3672874
chemical structure image
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
3
0
1.7
82.2
1
1
0
1.7
70.9
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
82.2
0
1.7
70.9
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Cobalamin (Cbl, vitamin B12) transport and metabolism
Degradation of the extracellular matrix
Extracellular matrix organization
Metabolism
Protein-Protein Interactions (80)
1 – 10 of 80
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.974112244
p_ni: 0.025887756
Score: 0.166
Data Source: BioPlex,STRINGDB
ADGRV1
Tbio
Family: GPCR
Novelty: 0.01398129
p_int: 0.924309536
p_ni: 0.075690464
Data Source: BioPlex
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.756896377
p_ni: 0.243103622
Data Source: BioPlex
KRT10
Tbio
Novelty: 0.00166073
Score: 0.957
Data Source: STRINGDB
KRT1
Tbio
Novelty: 0.00278467
Score: 0.95
Data Source: STRINGDB
CTRC
Tchem
Family: Enzyme
Novelty: 0.00457428
Score: 0.941
Data Source: Reactome,STRINGDB
KRT2
Tbio
Novelty: 0.01448252
Score: 0.932
Data Source: STRINGDB
SPINK1
Tbio
Family: Enzyme
Novelty: 0.00074416
Score: 0.924
Data Source: STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
Score: 0.916
Data Source: STRINGDB
MMP1
Tchem
Family: Enzyme
Novelty: 0.00030922
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  614.78

PubMed score by year
PubTator Score  365.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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