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Tbio
IVL
Involucrin

Protein Summary
Description
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368764
  • ENSP00000357753
  • ENSG00000163207
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.93
cell type or tissue
0.76
cellular component
0.62
chemical
0.6
gene perturbation
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 922.67   (req: < 5)
View Publications
Gene RIFs: 35   (req: <= 3)
View Gene RIFs
Antibodies: 701   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 922.67   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (194)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
Formation of the cornified envelope
75 targets
R-HSA-6809371
Reactome
Keratinization
217 targets
R-HSA-6805567
Name
Explore in Pharos
Explore in Source
Developmental Biology
1055 targets
R-HSA-1266738
Formation of the cornified envelope
75 targets
R-HSA-6809371
Keratinization
217 targets
R-HSA-6805567
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
protein binding, bridging
Inferred from Direct Assay (IDA)
UniProtKB
structural molecule activity
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (136)
1 – 10 of 136
KLHL11
Tdark
Novelty: 0.39728266
p_int: 0.99994791
p_ni: 0.00005209
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 6
p_int: 0.999940391
p_ni: 0.000059609
Data Source: BioPlex
TEFM
Tbio
Novelty: 0.13341034
p_int: 0.999898573
p_ni: 0.000101427
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.00913312
p_int: 0.999832315
p_ni: 0.000167685
Data Source: BioPlex
PDE4DIP
Tbio
Novelty: 0.04181178
p_int: 0.999828769
p_ni: 0.000171227
p_wrong: 4e-9
Data Source: BioPlex
CCNYL1
Tdark
Novelty: 0.8
p_int: 0.999717336
p_ni: 0.000282664
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.05099873
p_int: 0.999373289
p_ni: 0.000626711
Data Source: BioPlex
RBM24
Tbio
Novelty: 0.05713269
p_int: 0.999196487
p_ni: 0.000803506
p_wrong: 7e-9
Data Source: BioPlex
CDK15
Tchem
Family: Kinase
Novelty: 3.88235294
p_int: 0.99909543
p_ni: 0.00090457
Data Source: BioPlex
HSF2
Tbio
Family: TF
Novelty: 0.08966376
p_int: 0.998784145
p_ni: 0.001215855
Data Source: BioPlex
Publication Statistics
PubMed Score  922.67

PubMed score by year
PubTator Score  211.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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