Protein Summary
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 922.67 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 701 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 922.67 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 701 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (194)
Reactome (3)
PathwayCommons (1)
WikiPathways (190)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Gene Ontology Terms (13)
Functions (2)
Components (6)
Processes (5)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (136)
1 – 10 of 136
KLHL11
Novelty: 0.39728266
p_int: 0.99994791
p_ni: 0.00005209
Data Source: BioPlex
TBC1D22B
Novelty: 6
p_int: 0.999940391
p_ni: 0.000059609
Data Source: BioPlex
TEFM
Novelty: 0.13341034
p_int: 0.999898573
p_ni: 0.000101427
Data Source: BioPlex
FCF1
Novelty: 0.00913312
p_int: 0.999832315
p_ni: 0.000167685
Data Source: BioPlex
PDE4DIP
Novelty: 0.04181178
p_int: 0.999828769
p_ni: 0.000171227
p_wrong: 4e-9
Data Source: BioPlex
CCNYL1
Novelty: 0.8
p_int: 0.999717336
p_ni: 0.000282664
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.05099873
p_int: 0.999373289
p_ni: 0.000626711
Data Source: BioPlex
RBM24
Novelty: 0.05713269
p_int: 0.999196487
p_ni: 0.000803506
p_wrong: 7e-9
Data Source: BioPlex
CDK15
Family: Kinase
Novelty: 3.88235294
p_int: 0.99909543
p_ni: 0.00090457
Data Source: BioPlex
HSF2
Family: TF
Novelty: 0.08966376
p_int: 0.998784145
p_ni: 0.001215855
Data Source: BioPlex
Publication Statistics
PubMed Score 922.67
PubMed score by year
PubTator Score 211.3
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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