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Tclin
CA3
Carbonic anhydrase 3

Protein Summary
Description
Reversible hydration of carbon dioxide. Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285381
  • ENSP00000285381
  • ENSG00000164879

Symbol
  • Car3
  • CAIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.9
PubMedID
0.83
gene perturbation
0.7
protein domain
0.58
chemical
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.77   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 724.77   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
40.7
glomerular filtration rate
1
1
1
30.6
mean corpuscular hemoglobin concentration
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
40.7
glomerular filtration rate
1
30.6
mean corpuscular hemoglobin concentration
1
16
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 3
703801
Mouse
MGI:88270
12350
Rat
RGD:2241
54232
Dog
carbonic anhydrase 3
VGNC:38611
487032
Horse
carbonic anhydrase 3
VGNC:15964
100050125
Species
Name
OMA
EggNOG
Inparanoid
Macaque
carbonic anhydrase 3
Mouse
Rat
Dog
carbonic anhydrase 3
Horse
carbonic anhydrase 3
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07451-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Reversible hydration of carbon dioxide
Name
Explore in Pharos
Explore in Source
Metabolism
Reversible hydration of carbon dioxide
Protein-Protein Interactions (51)
1 – 10 of 51
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.975865482
p_ni: 0.012654169
p_wrong: 0.011480349
Data Source: BioPlex
TTC3
Tbio
Family: Enzyme
Novelty: 0.03120223
Score: 0.794
Data Source: STRINGDB
CYP24A1
Tchem
Family: Enzyme
Novelty: 0.00107155
Score: 0.738
Data Source: STRINGDB
GGT2
Tbio
Family: Enzyme
Novelty: 0.00399971
Score: 0.687
Data Source: STRINGDB
GGTLC3
Tdark
Family: Enzyme
Novelty: 0.00416359
Score: 0.687
Data Source: STRINGDB
GGT1
Tbio
Family: Enzyme
Novelty: 0.00252374
Score: 0.687
Data Source: STRINGDB
CAGE1
Tbio
Novelty: 0.00090205
Score: 0.668
Data Source: STRINGDB
TAAR9
Tbio
Family: GPCR
Novelty: 0.0059924
Score: 0.647
Data Source: STRINGDB
UHMK1
Tbio
Family: Kinase
Novelty: 0.04117277
Score: 0.644
Data Source: STRINGDB
SUGCT
Tbio
Family: Enzyme
Novelty: 0.0075902
Score: 0.63
Data Source: STRINGDB
Publication Statistics
PubMed Score  724.77

PubMed score by year
PubTator Score  1730.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer