Tbio MT1B Metallothionein-1B

Protein Summary

Description

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P07438
• Q86YX0
• MT-1B

Gene Name

• MT1B

Ensembl ID

• ENST00000334346
• ENSP00000334998
• ENSG00000169688

Symbol

• MT1Q
• MT1
• MTP
• MT1Q
• MT-1B
• MT-IB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
virus perturbation	0.72
PubMedID	0.55
metabolite	0.45
tissue	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.45   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 25   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.45   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0