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Tclin
TUBB
Tubulin beta chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327892
  • ENSP00000339001
  • ENSG00000196230
  • ENST00000383564
  • ENSP00000373058
  • ENSG00000183311
  • ENST00000419792
  • ENSP00000401317
  • ENSG00000235067
  • ENST00000421473
  • ENSP00000399155
  • ENSG00000224156
  • ENST00000422650
  • ENSP00000400663
  • ENSG00000229684
  • ENST00000422674
  • ENSP00000406811
  • ENSG00000227739
  • ENST00000432462
  • ENSP00000410829
  • ENSG00000232421
  • ENST00000436628
  • ENSP00000410071
  • ENSG00000232575

Symbol
  • TUBB5
  • M40
  • TUBB1
  • TUBB5
  • CDCBM6
  • CSCSC1
  • OK/SW-cl.56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.38   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 921   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.38   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 921   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Active Ligands (1)
1 – 1 of 1
colchicine
Rendered image for colchicine
GWAS Traits (162)
Items per page:
1 – 5 of 162
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
85.8
2
2
0
1.1
85.8
2
2
0
1.1
85.8
2
2
0
1.1
85.8
2
2
0
1.1
85.8
Items per page:
1 – 5 of 162
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.8
0
1.1
85.8
0
1.1
85.8
0
1.1
85.8
0
1.1
85.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tubulin beta class I
574113
Mouse
MGI:107812
22154
Rat
RGD:628596
29214
Dog
tubulin beta class I
474830
Horse
tubulin beta class I
VGNC:49368
100051013
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tubulin beta class I
Mouse
Rat
Dog
tubulin beta class I
Horse
tubulin beta class I
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07437-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (89)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (33)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (368)
1 – 10 of 368
ARL2
Tbio
Family:  Enzyme
Novelty:  0.01989908
p_int:  0.999998154
p_ni:  0.000001846
Score:  0.621
Data Source:  BioPlex,STRINGDB
TBCD
Tbio
Novelty:  0.01161221
p_int:  0.999939842
p_ni:  0.000060158
Score:  0.811
Data Source:  BioPlex,STRINGDB
TTC5
Tbio
Novelty:  0.12127698
p_int:  0.999777163
p_ni:  0.000222837
Score:  0.554
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.995895241
p_ni:  0.004104759
Score:  0.2
Data Source:  BioPlex,STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
p_int:  0.995361263
p_ni:  0.004638737
Data Source:  BioPlex
TCP11L1
Tdark
Novelty:  1.5011461
p_int:  0.992960857
p_ni:  0.007039143
Score:  0.839
Data Source:  BioPlex,STRINGDB
EPHA4
Tchem
Family:  Kinase
Novelty:  0.00321698
p_int:  0.98695319
p_ni:  0.01304681
Score:  0.158
Data Source:  BioPlex,STRINGDB
EML1
Tbio
Novelty:  0.02262549
p_int:  0.986882784
p_ni:  0.013117216
Score:  0.827
Data Source:  BioPlex,STRINGDB
ZNHIT6
Tbio
Novelty:  1.1021845
p_int:  0.983915895
p_ni:  0.016084094
p_wrong:  1.2e-8
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.981458425
p_ni:  0.01854157
p_wrong:  5e-9
Score:  0.397
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  233.38

PubMed score by year
PubTator Score  60.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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