Tclin TUBB Tubulin beta chain

Protein Summary

Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• P07437
• P05218
• Q8WUC1
• Q9CY33

Gene Name

• TUBB

Ensembl ID

• ENST00000327892
• ENSP00000339001
• ENSG00000196230
• ENST00000383564
• ENSP00000373058
• ENSG00000183311
• ENST00000419792
• ENSP00000401317
• ENSG00000235067
• ENST00000421473
• ENSP00000399155
• ENSG00000224156
• ENST00000422650
• ENSP00000400663
• ENSG00000229684
• ENST00000422674
• ENSP00000406811
• ENSG00000227739
• ENST00000432462
• ENSP00000410829
• ENSG00000232421
• ENST00000436628
• ENSP00000410071
• ENSG00000232575

Symbol

• TUBB5
• M40
• TUBB1
• TUBB5
• CDCBM6
• CSCSC1
• OK/SW-cl.56

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
kinase perturbation	0.99
molecular function	0.99
transcription factor perturbation	0.98

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta Chain

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Tubulin / Tubulin Beta Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 290.91   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 921   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 290.91   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 921   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14