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Tbio
C8G
Complement component C8 gamma chain

Protein Summary
Description
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224181
  • ENSP00000224181
  • ENSG00000176919
  • ENST00000371634
  • ENSP00000360697

Symbol
  • C8C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.74
disease perturbation
0.62
tissue sample
0.61
cellular component
0.57


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C8 gamma chain
VGNC:50890
100610119
Macaque
complement C8 gamma chain
721647
Mouse
MGI:88237
69379
Rat
RGD:1309074
296545
Dog
complement C8 gamma chain
VGNC:38602
480672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C8 gamma chain
Macaque
complement C8 gamma chain
Mouse
Rat
Dog
complement C8 gamma chain
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Reactome
Terminal pathway of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Terminal pathway of complement
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
S1PR2
Tchem
Family: GPCR
Novelty: 0.00372765
p_int: 0.999988155
p_ni: 1.2e-7
p_wrong: 0.000011724
Score: 0.189
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.999913917
p_ni: 0.000086083
Data Source: BioPlex
CEMIP2
Tbio
Novelty: 0.04698236
p_int: 0.981899212
p_ni: 0.018099459
p_wrong: 0.00000133
Score: 0.221
Data Source: BioPlex,STRINGDB
SH3GL1
Tbio
Novelty: 0.02379336
p_int: 0.973885829
p_ni: 0.026114133
p_wrong: 3.8e-8
Score: 0.232
Data Source: BioPlex,STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.970869615
p_ni: 0.029130385
Data Source: BioPlex
POLG
Tchem
Family: Enzyme
Novelty: 0.00172189
p_int: 0.953267653
p_ni: 0.046732173
p_wrong: 1.75e-7
Data Source: BioPlex
SEC24B
Tbio
Novelty: 0.01031644
p_int: 0.944426376
p_ni: 0.055573624
Score: 0.282
Data Source: BioPlex,STRINGDB
EDEM2
Tbio
Family: Enzyme
Novelty: 0.1180208
p_int: 0.828223293
p_ni: 0.171775921
p_wrong: 7.87e-7
Data Source: BioPlex
C8A
Tbio
Novelty: 0.00429321
Score: 0.997
Data Source: Reactome,STRINGDB
C8B
Tbio
Novelty: 0.00873524
Score: 0.995
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  39.44

PubMed score by year
PubTator Score  15.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer