Tbio GP1BA Platelet glycoprotein Ib alpha chain

Protein Summary

Description

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

Uniprot Accession IDs

• P07359
• E7ES66
• Q14441
• Q16469
• Q8N1F3
• Q8NG39
• Q9HDC7
• Q9UEK1
• Q9UQS4
• GP-Ib alpha

Gene Name

• GP1BA

Ensembl ID

• ENST00000329125
• ENSP00000329380
• ENSG00000185245

Symbol

• BSS
• GP1B
• VWDP
• CD42B
• GPIbA
• BDPLT1
• BDPLT3
• DBPLT3
• GPIbalpha
• CD42b-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
biological term	0.71
cellular component	0.67
disease	0.67
phenotype	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / Platelet Glycoprotein Ib Alpha Chain

Protein / Extracellular Matrix Protein / Platelet Glycoprotein Ib Alpha Chain

DTO Classes

Protein / Receptor / Platelet Glycoprotein Ib Alpha Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.19   (req: < 5)

Gene RIFs: 188   (req: <= 3)

Antibodies: 830   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 760.19   (req: >= 5)

Gene RIFs: 188   (req: > 3)

Antibodies: 830   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0