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Tbio
C8B
Complement component C8 beta chain

Protein Summary
Description
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371237
  • ENSP00000360281
  • ENSG00000021852

Symbol
  • C82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.81
disease
0.47
cell line
0.46
tissue
0.44


Related Tools
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.86   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.86   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
2
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
2
46.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C8 beta chain
VGNC:14307
456887
Macaque
complement C8 beta chain
716155
Mouse
MGI:88236
110382
Rat
RGD:2239
313421
Dog
complement C8 beta chain
VGNC:38601
479555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C8 beta chain
Macaque
complement C8 beta chain
Mouse
Rat
Dog
complement C8 beta chain
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07358-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Reactome
Terminal pathway of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Terminal pathway of complement
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (107)
1 – 10 of 107
DPY19L3
Tbio
Family: Enzyme
Novelty: 0.35244121
p_int: 0.999999989
p_ni: 1.1e-8
Data Source: BioPlex
PAPSS2
Tbio
Family: Enzyme
Novelty: 0.01538798
p_int: 0.999989677
p_ni: 0.00001032
p_wrong: 3e-9
Data Source: BioPlex
KDM1B
Tbio
Family: Epigenetic
Novelty: 0.02174039
p_int: 0.998865688
p_ni: 0.001134289
p_wrong: 2.4e-8
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.810564824
p_ni: 0.189435176
Data Source: BioPlex
C8A
Tbio
Novelty: 0.00429321
Score: 0.997
Data Source: Reactome,STRINGDB
C8G
Tbio
Novelty: 0.02322575
Score: 0.995
Data Source: Reactome,STRINGDB
C5
Tclin
Novelty: 0.00225386
Score: 0.978
Data Source: Reactome,STRINGDB
C9
Tbio
Novelty: 0.00749298
Score: 0.956
Data Source: Reactome,STRINGDB
CLU
Tbio
Novelty: 0.00054776
Score: 0.949
Data Source: Reactome,STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.941
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  108.86

PubMed score by year
PubTator Score  127.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer