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Tbio
C8A
Complement component C8 alpha chain

Protein Summary
Description
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361249
  • ENSP00000354458
  • ENSG00000157131
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.89
cell line
0.7
PubMedID
0.63
gene perturbation
0.56


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.74   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.74   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C8 alpha chain
VGNC:8243
456886
Macaque
complement C8 alpha chain
716114
Mouse
MGI:2668347
230558
Rat
RGD:1308355
298288
Dog
complement C8 alpha chain
VGNC:38600
100855712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C8 alpha chain
Macaque
complement C8 alpha chain
Mouse
Rat
Dog
complement C8 alpha chain
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07357-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Reactome
Terminal pathway of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Terminal pathway of complement
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (141)
1 – 10 of 141
MESD
Tbio
Novelty: 0.02639297
p_int: 0.999942288
p_ni: 0.000057712
Data Source: BioPlex
TAF7
Tbio
Novelty: 0.05316615
p_int: 0.99128154
p_ni: 0.008571334
p_wrong: 0.000147126
Data Source: BioPlex
CMIP
Tbio
Novelty: 0.0076969
p_int: 0.986433649
p_ni: 0.013446662
p_wrong: 0.000119689
Data Source: BioPlex
MMP14
Tchem
Family: Enzyme
Novelty: 0.00083836
p_int: 0.983676656
p_ni: 0.016323258
p_wrong: 8.6e-8
Data Source: BioPlex
ZMYM2
Tbio
Novelty: 0.0258698
p_int: 0.983343222
p_ni: 0.016656778
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.960008365
p_ni: 0.039991635
Data Source: BioPlex
TWSG1
Tbio
Novelty: 0.00255544
p_int: 0.923497102
p_ni: 0.076055219
p_wrong: 0.000447678
Data Source: BioPlex
FBLN1
Tbio
Novelty: 0.00796703
p_int: 0.847832054
p_ni: 0.152167946
Score: 0.173
Data Source: BioPlex,STRINGDB
EEF1A1
Tchem
Novelty: 0.00059953
p_int: 0.841353813
p_ni: 0.158646187
Data Source: BioPlex
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.837854416
p_ni: 0.162145577
p_wrong: 6e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  222.74

PubMed score by year
PubTator Score  73.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer