Tbio ANXA2 Annexin A2

Protein Summary

Description

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07355
• Q567R4
• Q6N0B3
• Q8TBV2
• Q96DD5
• Q9UDH8

Gene Name

• ANXA2

Ensembl ID

• ENST00000332680
• ENSP00000346032
• ENSG00000182718
• ENST00000396024
• ENSP00000379342
• ENST00000421017
• ENSP00000411352
• ENST00000451270
• ENSP00000387545

Symbol

• ANX2
• ANX2L4
• CAL1H
• LPC2D
• P36
• ANX2
• LIP2
• LPC2
• CAL1H
• LPC2D
• ANX2L4
• PAP-IV
• HEL-S-270

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
transcription factor perturbation	1
disease perturbation	0.99
hub protein	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.68   (req: < 5)

Gene RIFs: 396   (req: <= 3)

Antibodies: 772   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1206.68   (req: >= 5)

Gene RIFs: 396   (req: > 3)

Antibodies: 772   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0