Tbio ANXA2 Annexin A2

Protein Summary

Description

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07355
• Q567R4
• Q6N0B3
• Q8TBV2
• Q96DD5
• Q9UDH8

Gene Name

• ANXA2

Ensembl ID

• ENST00000332680
• ENSP00000346032
• ENSG00000182718
• ENST00000396024
• ENSP00000379342
• ENST00000421017
• ENSP00000411352
• ENST00000451270
• ENSP00000387545

Symbol

• ANX2
• ANX2L4
• CAL1H
• LPC2D
• P36
• ANX2
• LIP2
• LPC2
• CAL1H
• LPC2D
• ANX2L4
• PAP-IV
• HEL-S-270

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
transcription factor perturbation	1
disease perturbation	0.99
hub protein	0.99

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.04   (req: < 5)

Gene RIFs: 299   (req: <= 3)

Antibodies: 772   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1116.04   (req: >= 5)

Gene RIFs: 299   (req: > 3)

Antibodies: 772   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (269)

Explore Interacting Targets

1 – 10 of 269

• See Interactions on String-DB

S100A10

Tbio

Novelty:  0.00281525

p_int:  0.999958471

p_ni:  0.000041529

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

ANXA13

Tbio

Novelty:  0.01534307

p_int:  0.997750335

p_ni:  0.000014049

p_wrong:  0.002235617

Score:  0.557

Data Source:  BioPlex,STRINGDB

AHNAK2

Tbio

Novelty:  0.05663435

p_int:  0.937156763

p_ni:  0.062843237

Score:  0.339

Data Source:  BioPlex,STRINGDB

KLHL42

Tdark

Novelty:  0.25822395

p_int:  0.781803796

p_ni:  0.218196204

Score:  0.188

Data Source:  BioPlex,STRINGDB

S100A4

Tchem

Novelty:  0.00136919

Score:  0.991

Data Source:  STRINGDB

PLG

Tclin

Family:  Enzyme

Novelty:  0.00004806

Score:  0.99

Data Source:  STRINGDB

DYSF

Tbio

Novelty:  0.00248634

Score:  0.985

Data Source:  Reactome,STRINGDB

PLAT

Tclin

Family:  Enzyme

Novelty:  0.00017503

Score:  0.973

Data Source:  STRINGDB

RPS6KA1

Tchem

Family:  Kinase

Novelty:  0.00178073

Score:  0.952

Data Source:  STRINGDB

TRIM72

Tbio

Novelty:  0.01480557

Score:  0.949

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (12)

PathwayCommons (2)

WikiPathways (2)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Reactome	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37 targets	R-HSA-8950505
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37 targets	R-HSA-8950505
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (83)

Functions (18)

Components (32)

Processes (33)

Find Similar Targets

Items per page:

10

1 – 10 of 18

GO Term	Evidence	Assigned by
calcium-dependent phospholipid binding	Inferred from Direct Assay (IDA)	UniProtKB
molecular function regulator	Inferred from Direct Assay (IDA)	BHF-UCL
phospholipase A2 inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
calcium-dependent protein binding	Inferred from Physical Interaction (IPI)	AgBase
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protease binding	Inferred from Physical Interaction (IPI)	BHF-UCL
S100 protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
cadherin binding involved in cell-cell adhesion	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (6)

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1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menarche	EFO_0004703	1	1	1		58.4
puberty onset measurement	EFO_0005677	1	1	1		54.4
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		52
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		33.1
eosinophil count	EFO_0004842	1	1	1		30.2

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menarche	EFO_0004703	1		58.4
puberty onset measurement	EFO_0005677	1		54.4
eosinophil percentage of leukocytes	EFO_0007991	1		52
serum gamma-glutamyl transferase measurement	EFO_0004532	1		33.1
eosinophil count	EFO_0004842	1		30.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Annexin
Basement membrane
Calcium
Calcium/phospholipid-binding
Complete proteome
Direct protein sequencing
Extracellular matrix

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
eosinophil count
eosinophil percentage of leukocytes
puberty onset measurement
serum gamma-glutamyl transferase measurement
testosterone measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	annexin A2	VGNC:11803	747018
Macaque	annexin A2		706240
Mouse	annexin A2	MGI:88246	12306
Rat	annexin A2	RGD:621170	56611
Dog	annexin A2		403435

Species	Name	OMA	EggNOG	Inparanoid
Chimp	annexin A2
Macaque	annexin A2
Mouse	annexin A2
Rat	annexin A2
Dog	annexin A2

Publication Statistics

PubMed Score 1116.04

PubMed score by year

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PubTator Score 860.66

PubTator score by year

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Related Publications

Text Mined References (388)

GeneRif Annotations (299)

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PMID	Year	Title