Protein Summary
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000332680
- ENSP00000346032
- ENSG00000182718
- ENST00000396024
- ENSP00000379342
- ENST00000421017
- ENSP00000411352
- ENST00000451270
- ENSP00000387545
- ANX2
- ANX2L4
- CAL1H
- LPC2D
- P36
- ANX2
- LIP2
- LPC2
- CAL1H
- LPC2D
- ANX2L4
- PAP-IV
- HEL-S-270
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 1 | ||
transcription factor perturbation | 1 | ||
disease perturbation | 0.99 | ||
hub protein | 0.99 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1085.37 (req: < 5)
Gene RIFs: 299 (req: <= 3)
Antibodies: 772 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1085.37 (req: >= 5)
Gene RIFs: 299 (req: > 3)
Antibodies: 772 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 51
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | annexin A2 | VGNC:11803 | 747018 | |||||
Macaque | annexin A2 | 706240 | ||||||
Mouse | MGI:88246 | 12306 | ||||||
Rat | RGD:621170 | 56611 | ||||||
Dog | annexin A2 | 403435 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | annexin A2 | |||||
Macaque | annexin A2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | annexin A2 | |||||
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (12)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Dissolution of Fibrin Clot | ||||
Reactome | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Dissolution of Fibrin Clot | ||||
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Hemostasis | ||||
Immune System | ||||
Gene Ontology Terms (83)
Functions (18)
Components (32)
Processes (33)
Items per page:
10
1 – 10 of 18
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Protein-Protein Interactions (269)
1 – 10 of 269
S100A10
Novelty: 0.00281525
p_int: 0.999958471
p_ni: 0.000041529
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ANXA13
Novelty: 0.01534307
p_int: 0.997750335
p_ni: 0.000014049
p_wrong: 0.002235617
Score: 0.557
Data Source: BioPlex,STRINGDB
AHNAK2
Novelty: 0.05663435
p_int: 0.937156763
p_ni: 0.062843237
Score: 0.339
Data Source: BioPlex,STRINGDB
KLHL42
Novelty: 0.25822395
p_int: 0.781803796
p_ni: 0.218196204
Score: 0.188
Data Source: BioPlex,STRINGDB
S100A4
Novelty: 0.00136919
Score: 0.991
Data Source: STRINGDB
PLG
Family: Enzyme
Novelty: 0.00004806
Score: 0.99
Data Source: STRINGDB
DYSF
Novelty: 0.00248634
Score: 0.985
Data Source: Reactome,STRINGDB
PLAT
Family: Enzyme
Novelty: 0.00017503
Score: 0.973
Data Source: STRINGDB
RPS6KA1
Family: Kinase
Novelty: 0.00178073
Score: 0.952
Data Source: STRINGDB
TRIM72
Novelty: 0.01480557
Score: 0.949
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 1085.37
PubMed score by year
PubTator Score 860.66
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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