Tbio ANXA2 Annexin A2

Protein Summary

Description

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640). This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07355
• Q567R4
• Q6N0B3
• Q8TBV2
• Q96DD5
• Q9UDH8

Gene Name

• ANXA2

Ensembl ID

• ENST00000332680
• ENSP00000346032
• ENSG00000182718
• ENST00000396024
• ENSP00000379342
• ENST00000421017
• ENSP00000411352
• ENST00000451270
• ENSP00000387545

Symbol

• ANX2
• ANX2L4
• CAL1H
• LPC2D
• P36
• ANX2
• LIP2
• LPC2
• CAL1H
• LPC2D
• ANX2L4
• PAP-IV
• HEL-S-270

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
kinase perturbation	1
transcription factor perturbation	1
disease perturbation	0.99
hub protein	0.99

Related Tools

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1085.37   (req: < 5)

Gene RIFs: 299   (req: <= 3)

Antibodies: 772   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1085.37   (req: >= 5)

Gene RIFs: 299   (req: > 3)

Antibodies: 772   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	annexin A2	VGNC:11803	747018
Macaque	annexin A2		706240
Mouse	annexin A2	MGI:88246	12306
Rat	annexin A2	RGD:621170	56611
Dog	annexin A2		403435

Species	Name	OMA	EggNOG	Inparanoid
Chimp	annexin A2
Macaque	annexin A2
Mouse	annexin A2
Rat	annexin A2
Dog	annexin A2

Protein Structure (15 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07355-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (16)

Reactome (12)

PathwayCommons (2)

WikiPathways (2)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets

Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Reactome	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37 targets	R-HSA-8950505
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Dissolution of Fibrin Clot	13 targets	R-HSA-75205
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	37 targets	R-HSA-8950505
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (83)

Functions (18)

Components (32)

Processes (33)

Find Similar Targets

Items per page:

10

1 – 10 of 18

GO Term	Evidence	Assigned by
calcium-dependent phospholipid binding	Inferred from Direct Assay (IDA)	UniProtKB
molecular function regulator	Inferred from Direct Assay (IDA)	BHF-UCL
phospholipase A2 inhibitor activity	Inferred from Direct Assay (IDA)	UniProtKB
calcium-dependent protein binding	Inferred from Physical Interaction (IPI)	AgBase
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protease binding	Inferred from Physical Interaction (IPI)	BHF-UCL
S100 protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
cadherin binding involved in cell-cell adhesion	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (269)

Explore Interacting Targets

1 – 10 of 269

• See Interactions on String-DB

S100A10

Tbio

Novelty: 0.00281525

p_int: 0.999958471

p_ni: 0.000041529

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

ANXA13

Tbio

Novelty: 0.01534307

p_int: 0.997750335

p_ni: 0.000014049

p_wrong: 0.002235617

Score: 0.557

Data Source: BioPlex,STRINGDB

AHNAK2

Tbio

Novelty: 0.05663435

p_int: 0.937156763

p_ni: 0.062843237

Score: 0.339

Data Source: BioPlex,STRINGDB

KLHL42

Tdark

Novelty: 0.25822395

p_int: 0.781803796

p_ni: 0.218196204

Score: 0.188

Data Source: BioPlex,STRINGDB

S100A4

Tbio

Novelty: 0.00136919

Score: 0.991

Data Source: STRINGDB

PLG

Tclin

Family: Enzyme

Novelty: 0.00004806

Score: 0.99

Data Source: STRINGDB

DYSF

Tbio

Novelty: 0.00248634

Score: 0.985

Data Source: Reactome,STRINGDB

PLAT

Tclin

Family: Enzyme

Novelty: 0.00017503

Score: 0.973

Data Source: STRINGDB

RPS6KA1

Tchem

Family: Kinase

Novelty: 0.00178073

Score: 0.952

Data Source: STRINGDB

TRIM72

Tbio

Novelty: 0.01480557

Score: 0.949

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  1085.37

PubMed score by year

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PubTator Score  860.66

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Alternative splicing
Annexin
Basement membrane
Calcium
Calcium/phospholipid-binding
Complete proteome
Direct protein sequencing
Extracellular matrix

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype