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Tchem
CTSD
Cathepsin D

Protein Summary
Description
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236671
  • ENSP00000236671
  • ENSG00000117984

Symbol
  • CPSD
  • CPSD
  • CLN10
  • HEL-S-130P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
biological term
0.96
cellular component
0.94
kinase perturbation
0.88
chemical
0.86


Related Tools
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GENEVA
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3241.31   (req: < 5)
Gene RIFs: 170   (req: <= 3)
Antibodies: 1029   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3241.31   (req: >= 5)
Gene RIFs: 170   (req: > 3)
Antibodies: 1029   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 585
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin D measurement
1
1
1
81.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin D measurement
1
81.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cathepsin D
703534
Mouse
MGI:88562
13033
Rat
RGD:621511
171293
Dog
cathepsin D
483662
Cow
cathepsin D
282883
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cathepsin D
Mouse
Rat
Dog
cathepsin D
Cow
cathepsin D
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07339-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (250)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Collagen degradation
Degradation of the extracellular matrix
ESR-mediated signaling
Estrogen-dependent gene expression
Protein-Protein Interactions (319)
1 – 10 of 319
NAPSA
Tbio
Family: Enzyme
Novelty: 0.00486139
p_int: 0.802837157
p_ni: 0.197162843
Score: 0.688
Data Source: BioPlex,STRINGDB
CTSH
Tchem
Family: Enzyme
Novelty: 0.00336694
Score: 0.983
Data Source: STRINGDB
CST3
Tbio
Novelty: 0.00021856
Score: 0.972
Data Source: STRINGDB
CTSB
Tchem
Family: Enzyme
Novelty: 0.00026238
Score: 0.97
Data Source: STRINGDB
CTSZ
Tchem
Family: Enzyme
Novelty: 0.0100016
Score: 0.965
Data Source: STRINGDB
CSTB
Tbio
Novelty: 0.00311198
Score: 0.964
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.959
Data Source: STRINGDB
CTSS
Tchem
Family: Enzyme
Novelty: 0.00786042
Score: 0.959
Data Source: STRINGDB
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
Score: 0.944
Data Source: STRINGDB
ASAH1
Tchem
Family: Enzyme
Novelty: 0.00374228
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  3241.31

PubMed score by year
PubTator Score  2146.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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