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Tchem
CTSD
Cathepsin D

Protein Summary
Description
Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236671
  • ENSP00000236671
  • ENSG00000117984

Symbol
  • CPSD
  • CPSD
  • CLN10
  • HEL-S-130P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
biological term
0.96
cellular component
0.94
kinase perturbation
0.88
chemical
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3276.09   (req: < 5)
Gene RIFs: 170   (req: <= 3)
Antibodies: 1029   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3276.09   (req: >= 5)
Gene RIFs: 170   (req: > 3)
Antibodies: 1029   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 661
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (319)
1 – 10 of 319
NAPSA
Tbio
Family:  Enzyme
Novelty:  0.00486139
p_int:  0.802837157
p_ni:  0.197162843
Score:  0.688
Data Source:  BioPlex,STRINGDB
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
Score:  0.983
Data Source:  STRINGDB
CST3
Tbio
Novelty:  0.00021856
Score:  0.972
Data Source:  STRINGDB
CTSB
Tchem
Family:  Enzyme
Novelty:  0.00026238
Score:  0.97
Data Source:  STRINGDB
CTSZ
Tchem
Family:  Enzyme
Novelty:  0.0100016
Score:  0.965
Data Source:  STRINGDB
CSTB
Tbio
Novelty:  0.00311198
Score:  0.964
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.959
Data Source:  STRINGDB
CTSS
Tchem
Family:  Enzyme
Novelty:  0.00786042
Score:  0.959
Data Source:  STRINGDB
MMP9
Tchem
Family:  Enzyme
Novelty:  0.00008645
Score:  0.944
Data Source:  STRINGDB
ASAH1
Tchem
Family:  Enzyme
Novelty:  0.00374228
Score:  0.941
Data Source:  STRINGDB
Pathways (250)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Collagen degradation
Degradation of the extracellular matrix
ESR-mediated signaling
Estrogen-dependent gene expression
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin D measurement
1
3
3
96.9
monocyte count
2
1
2
85.4
blood protein measurement
1
1
1
82.8
monocyte percentage of leukocytes
2
1
2
82.6
aspartate aminotransferase measurement
1
1
0
7.1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin D measurement
3
96.9
monocyte count
2
85.4
blood protein measurement
1
82.8
monocyte percentage of leukocytes
2
82.6
aspartate aminotransferase measurement
0
7.1
56
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cathepsin D
703534
Mouse
MGI:88562
13033
Rat
RGD:621511
171293
Dog
cathepsin D
483662
Cow
cathepsin D
282883
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cathepsin D
Mouse
Rat
Dog
cathepsin D
Cow
cathepsin D
Publication Statistics
PubMed Score 3276.09
PubMed score by year
PubTator Score 2146.55
PubTator score by year