Tchem CTSD Cathepsin D

Protein Summary

Description

Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P07339
• Q6IB57

Gene Name

• CTSD

Ensembl ID

• ENST00000236671
• ENSP00000236671
• ENSG00000117984

Symbol

• CPSD
• CPSD
• CLN10
• HEL-S-130P

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
biological term	0.96
cellular component	0.94
kinase perturbation	0.88
chemical	0.86

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Aspartic Protease / Cathepsin D

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Cathepsin D

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3367.14   (req: < 5)

Gene RIFs: 205   (req: <= 3)

Antibodies: 1029   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3367.14   (req: >= 5)

Gene RIFs: 205   (req: > 3)

Antibodies: 1029   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 714

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0