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Tclin
CSF1R
Macrophage colony-stimulating factor 1 receptor

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286301
  • ENSP00000286301
  • ENSG00000182578
  • ENST00000543093
  • ENSP00000445282

Symbol
  • FMS
  • FMS
  • CSFR
  • FIM2
  • HDLS
  • C-FMS
  • CD115
  • CSF-1R
  • M-CSF-R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
biological process
0.99
disease perturbation
0.99
small molecule
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1503.44   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 1631   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1503.44   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 1631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 446
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
5
5
77.6
monocyte count
1
2
2
63.6
granulocyte percentage of myeloid white cells
1
2
2
61
neutrophil percentage of leukocytes
1
1
1
38.6
feeling emotionally hurt measurement
1
1
0
5.7
19.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
5
77.6
monocyte count
2
63.6
granulocyte percentage of myeloid white cells
2
61
neutrophil percentage of leukocytes
1
38.6
feeling emotionally hurt measurement
0
5.7
19.4
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Other interleukin signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Other interleukin signaling
Signaling by Interleukins
Gene Ontology Terms (55)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (363)
1 – 10 of 363
CSF1
Tbio
Novelty: 0.0005221
Score: 0.999
Data Source: Reactome,STRINGDB
IL34
Tbio
Novelty: 0.00838631
Score: 0.998
Data Source: Reactome,STRINGDB
SPI1
Tbio
Family: TF
Novelty: 0.00064309
Score: 0.988
Data Source: STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.964
Data Source: STRINGDB
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00410031
Score: 0.964
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.952
Data Source: STRINGDB
ITGAV
Tchem
Novelty: 0.00148589
Score: 0.945
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00067255
Score: 0.939
Data Source: STRINGDB
VAV3
Tbio
Novelty: 0.010944
Score: 0.931
Data Source: STRINGDB
PTPN1
Tchem
Family: Enzyme
Novelty: 0.00065779
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  1503.44

PubMed score by year
PubTator Score  594.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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