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Tclin
FES
Tyrosine-protein kinase Fes/Fps

Protein Summary
Description
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maint ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328850
  • ENSP00000331504
  • ENSG00000182511
  • ENST00000394300
  • ENSP00000377837
  • ENST00000414248
  • ENSP00000414629
  • ENST00000444422
  • ENSP00000400868

Symbol
  • FPS
  • FPS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.97
drug perturbation
0.87
biological process
0.86
cellular component
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.21   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 330.21   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
lorlatinib
chemical structure image
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
4
4
4
97.1
4
4
2
1.1
93.6
diastolic blood pressure
3
1
3
78.5
balding measurement
1
1
1
75.6
neutrophil count
1
1
1
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
4
97.1
2
1.1
93.6
diastolic blood pressure
3
78.5
balding measurement
1
75.6
neutrophil count
1
71.1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome
Sema3A PAK dependent Axon repulsion
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema3A PAK dependent Axon repulsion
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (146)
1 – 10 of 146
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.957
Data Source: STRINGDB
DPYSL5
Tbio
Family: Enzyme
Novelty: 0.0052536
Score: 0.951
Data Source: STRINGDB
JAK1
Tclin
Family: Kinase
Novelty: 0.00093625
Score: 0.947
Data Source: STRINGDB
PLXNA1
Tbio
Novelty: 0.01195083
Score: 0.947
Data Source: Reactome,STRINGDB
JAK3
Tclin
Family: Kinase
Novelty: 0.00164278
Score: 0.946
Data Source: STRINGDB
IL4R
Tclin
Novelty: 0.00359183
Score: 0.939
Data Source: STRINGDB
DPYSL2
Tbio
Family: Enzyme
Novelty: 0.00374969
Score: 0.939
Data Source: STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00179772
Score: 0.938
Data Source: STRINGDB
IRS2
Tbio
Novelty: 0.00164304
Score: 0.937
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.926
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  330.21

PubMed score by year
PubTator Score  6.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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