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Tclin
FES
Tyrosine-protein kinase Fes/Fps

Protein Summary
Description
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maint ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328850
  • ENSP00000331504
  • ENSG00000182511
  • ENST00000394300
  • ENSP00000377837
  • ENST00000414248
  • ENSP00000414629
  • ENST00000444422
  • ENSP00000400868

Symbol
  • FPS
  • FPS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.97
drug perturbation
0.87
biological process
0.86
cellular component
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333.41   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 333.41   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (146)
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.957
Data Source:  STRINGDB
DPYSL5
Tbio
Family:  Enzyme
Novelty:  0.0052536
Score:  0.951
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.947
Data Source:  STRINGDB
PLXNA1
Tbio
Novelty:  0.01195083
Score:  0.947
Data Source:  Reactome,STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.946
Data Source:  STRINGDB
IL4R
Tclin
Novelty:  0.00359183
Score:  0.939
Data Source:  STRINGDB
DPYSL2
Tbio
Family:  Enzyme
Novelty:  0.00374969
Score:  0.939
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.938
Data Source:  STRINGDB
IRS2
Tbio
Novelty:  0.00164304
Score:  0.937
Data Source:  STRINGDB
KIT
Tclin
Family:  Kinase
Novelty:  0.00011237
Score:  0.926
Data Source:  Reactome,STRINGDB
Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome
Sema3A PAK dependent Axon repulsion
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema3A PAK dependent Axon repulsion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
6
99.2
7
6
4
1.1
96
8
4
4
1.1
94.2
mean platelet volume
3
2
3
93.3
birth weight
4
4
4
90
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
99.2
4
1.1
96
4
1.1
94.2
mean platelet volume
3
93.3
birth weight
4
90
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FES proto-oncogene, tyrosine kinase
VGNC:8282
453654
Macaque
FES proto-oncogene, tyrosine kinase
715764
Mouse
MGI:95514
14159
Rat
RGD:1564385
361597
Dog
FES proto-oncogene, tyrosine kinase
VGNC:40825
609483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FES proto-oncogene, tyrosine kinase
Macaque
FES proto-oncogene, tyrosine kinase
Mouse
Rat
Dog
FES proto-oncogene, tyrosine kinase
Publication Statistics
PubMed Score 333.41
PubMed score by year
PubTator Score 6.87
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title