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Tbio
CRYGD
Gamma-crystallin D

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264376
  • ENSP00000264376
  • ENSG00000118231
  • ENST00000644920
  • ENSP00000496652
  • ENSG00000285434

Symbol
  • CRYG4
  • CCP
  • PCC
  • CACA
  • CCA3
  • CRYG4
  • CTRCT4
  • cry-g-D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
biological term
0.76
tissue
0.67
cell line
0.52
cellular component
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.84   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.84   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
FOPNL
Tbio
Novelty:  0.07640992
p_int:  0.999988495
p_ni:  0.0000115
p_wrong:  5e-9
Data Source:  BioPlex
CRYAA
Tchem
Novelty:  0.01914081
Score:  0.847
Data Source:  STRINGDB
CRYAA2
Tdark
Novelty:  0.01914081
Score:  0.814
Data Source:  STRINGDB
CRYAB
Tchem
Novelty:  0.00464213
Score:  0.805
Data Source:  STRINGDB
GJA3
Tbio
Novelty:  0.00638283
Score:  0.772
Data Source:  STRINGDB
GJA8
Tbio
Novelty:  0.00377739
Score:  0.76
Data Source:  STRINGDB
BFSP2
Tbio
Novelty:  0.00206411
Score:  0.749
Data Source:  STRINGDB
TMEM114
Tdark
Novelty:  0.25895358
Score:  0.699
Data Source:  STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
Score:  0.689
Data Source:  STRINGDB
LIM2
Tbio
Novelty:  0.01252353
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
42.3
1
1
0
1.2
42.3
1
1
0
1.2
42.3
1
1
0
1.2
42.3
daytime rest measurement
1
1
1
10.6
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
42.3
0
1.2
42.3
0
1.2
42.3
0
1.2
42.3
daytime rest measurement
1
10.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma D
VGNC:10732
459906
Mouse
MGI:88524
12967
Rat
RGD:1586353
689947
Dog
crystallin, gamma D
488495
Cow
crystallin, gamma D
281723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin gamma D
Mouse
Rat
Dog
crystallin, gamma D
Cow
crystallin, gamma D
Publication Statistics
PubMed Score 412.84
PubMed score by year
PubTator Score 393.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title