Tbio ACYP1 Acylphosphatase-1

Protein Summary

Description

Its physiological role is not yet clear. This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P07311
• A6NDV8
• B2R590

Gene Name

• ACYP1

Ensembl ID

• ENST00000238618
• ENSP00000238618
• ENSG00000119640
• ENST00000357971
• ENSP00000350655
• ENST00000555694
• ENSP00000451581

Symbol

• ACYPE
• ACYPE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.83
histone modification site profile	0.66
tissue sample	0.66
transcription factor binding site profile	0.64
pathway	0.59

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Acylphosphatase-1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Acylphosphatase-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.94   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.94   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0