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Tbio
ASGR1
Asialoglycoprotein receptor 1

Protein Summary
Description
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269299
  • ENSP00000269299
  • ENSG00000141505
  • ENST00000574388
  • ENSP00000459169
  • ENST00000619926
  • ENSP00000481182

Symbol
  • CLEC4H1
  • HL-1
  • ASGPR
  • ASGPR1
  • CLEC4H1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
disease perturbation
0.68
gene perturbation
0.67
tissue
0.56
histone modification site profile
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 525.47   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 525.47   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
PLVAP
Tbio
Novelty:  0.01230117
p_int:  0.999964967
p_ni:  0.000012305
p_wrong:  0.000022728
Score:  0.269
Data Source:  BioPlex,STRINGDB
PTPN2
Tchem
Family:  Enzyme
Novelty:  0.00372891
p_int:  0.999845072
p_ni:  0.000154861
p_wrong:  6.7e-8
Score:  0.324
Data Source:  BioPlex,STRINGDB
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
p_int:  0.77888664
p_ni:  0.221113359
p_wrong:  1e-9
Score:  0.384
Data Source:  BioPlex,STRINGDB
ASGR2
Tbio
Novelty:  0.14671716
Score:  0.971
Data Source:  Reactome,STRINGDB
CERS2
Tbio
Family:  TF
Novelty:  0.00994797
Score:  0.962
Data Source:  STRINGDB
TG
Tbio
Novelty:  0.00010111
Score:  0.898
Data Source:  STRINGDB
ST3GAL4
Tbio
Family:  Enzyme
Novelty:  0.00419433
Score:  0.808
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.711
Data Source:  STRINGDB
CES5A
Tbio
Family:  Enzyme
Novelty:  0.01165906
Score:  0.649
Data Source:  STRINGDB
CES4A
Tbio
Family:  Enzyme
Novelty:  0.14525977
Score:  0.648
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
6
5
15.8
99.4
low density lipoprotein cholesterol measurement
8
5
12
97
apolipoprotein B measurement
2
4
5
96.6
total cholesterol measurement
5
5
9
96.5
birth weight
4
3
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
5
15.8
99.4
low density lipoprotein cholesterol measurement
12
97
apolipoprotein B measurement
5
96.6
total cholesterol measurement
9
96.5
birth weight
4
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
asialoglycoprotein receptor 1
VGNC:6357
750596
Mouse
MGI:88081
11889
Rat
RGD:2160
24210
Horse
asialoglycoprotein receptor 1
VGNC:15580
100061471
Cow
asialoglycoprotein receptor 1
VGNC:26209
509121
Species
Name
OMA
EggNOG
Inparanoid
Chimp
asialoglycoprotein receptor 1
Mouse
Rat
Horse
asialoglycoprotein receptor 1
Cow
asialoglycoprotein receptor 1
Publication Statistics
PubMed Score 525.47
PubMed score by year
PubTator Score 241.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title