Protein Summary
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
- ENST00000340857
- ENSP00000344504
- ENSG00000189060
- H1FV
- H10
- H1FV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
transcription factor perturbation | 0.96 | ||
small molecule perturbation | 0.93 | ||
interacting protein | 0.92 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2389.43 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 681 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2389.43 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 681 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (7)
Active Ligands (0)
Protein-Protein Interactions (189)
Nearest Tclin Targets
Pathways (9)
Reactome (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptosis induced DNA fragmentation | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptosis induced DNA fragmentation | ||||
Apoptotic execution phase | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (5)
Components (9)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 4 | 3 | 5 | 82.9 | |||||
cup-to-disc ratio measurement | 2 | 2 | 2 | 78.9 | |||||
age-related hearing impairment | 2 | 1 | 1 | 1.1 | 76.8 | ||||
sex hormone-binding globulin measurement | 4 | 2 | 4 | 73 | |||||
brain measurement | 1 | 1 | 0 | 11.7 | 70.6 | ||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intraocular pressure measurement | 5 | 82.9 | |||||
cup-to-disc ratio measurement | 2 | 78.9 | |||||
age-related hearing impairment | 1 | 1.1 | 76.8 | ||||
sex hormone-binding globulin measurement | 4 | 73 | |||||
brain measurement | 0 | 11.7 | 70.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | H1 histone family member 0 | VGNC:14352 | 743278 | |||||
Mouse | MGI:95893 | 14958 | ||||||
Cow | H1 histone family, member 0 | 617975 | ||||||
Xenopus | H1 histone family member 0 | XB-GENE-480028 | 407939 | |||||
Zebrafish | ZDB-GENE-030131-337 | 321618 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | H1 histone family member 0 | |||||
Mouse | ||||||
Cow | H1 histone family, member 0 | |||||
Xenopus | H1 histone family member 0 | |||||
Zebrafish | ||||||
Publication Statistics
PubMed Score 2389.43
PubMed score by year
PubTator Score 388.53
PubTator score by year
Related Publications
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Text |
|---|