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Tchem
H1F0
Histone H1.0

Protein Summary
Description
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340857
  • ENSP00000344504
  • ENSG00000189060

Symbol
  • H1FV
  • H10
  • H1FV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.96
small molecule perturbation
0.93
interacting protein
0.92
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2389.43   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2389.43   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (189)
H1FX
Tbio
Novelty:  0.02497936
Score:  0.993
Data Source:  STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
Score:  0.96
Data Source:  Reactome,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
Score:  0.956
Data Source:  STRINGDB
DFFB
Tbio
Novelty:  0.00475349
Score:  0.951
Data Source:  Reactome,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.95
Data Source:  STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.94
Data Source:  STRINGDB
HMGB1
Tchem
Family:  TF
Novelty:  0.00043845
Score:  0.939
Data Source:  STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
Score:  0.933
Data Source:  STRINGDB
HMGA1
Tbio
Family:  TF
Novelty:  0.00185669
Score:  0.932
Data Source:  Reactome,STRINGDB
HIST1H1D
Tbio
Novelty:  0.00922175
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
3
5
82.9
cup-to-disc ratio measurement
2
2
2
78.9
age-related hearing impairment
2
1
1
1.1
76.8
sex hormone-binding globulin measurement
4
2
4
73
brain measurement
1
1
0
11.7
70.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
82.9
cup-to-disc ratio measurement
2
78.9
age-related hearing impairment
1
1.1
76.8
sex hormone-binding globulin measurement
4
73
brain measurement
0
11.7
70.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member 0
VGNC:14352
743278
Mouse
MGI:95893
14958
Cow
H1 histone family, member 0
617975
Xenopus
H1 histone family member 0
XB-GENE-480028
407939
Zebrafish
ZDB-GENE-030131-337
321618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member 0
Mouse
Cow
H1 histone family, member 0
Xenopus
H1 histone family member 0
Zebrafish
Publication Statistics
PubMed Score 2389.43
PubMed score by year
PubTator Score 388.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text