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Tchem
H1F0
Histone H1.0

Protein Summary
Description
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340857
  • ENSP00000344504
  • ENSG00000189060

Symbol
  • H1FV
  • H10
  • H1FV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.96
small molecule perturbation
0.93
interacting protein
0.92
kinase perturbation
0.76


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2292.42   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2292.42   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member 0
VGNC:14352
743278
Mouse
MGI:95893
14958
Cow
H1 histone family, member 0
617975
Xenopus
H1 histone family member 0
XB-GENE-480028
407939
Zebrafish
ZDB-GENE-030131-337
321618
Species
Name
OMA
EggNOG
Inparanoid
Chimp
H1 histone family member 0
Mouse
Cow
H1 histone family, member 0
Xenopus
H1 histone family member 0
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P07305-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (189)
1 – 10 of 189
H1FX
Tbio
Novelty: 0.02497936
Score: 0.993
Data Source: STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
Score: 0.96
Data Source: Reactome,STRINGDB
H1FOO
Tbio
Novelty: 0.02189067
Score: 0.956
Data Source: STRINGDB
DFFB
Tbio
Novelty: 0.00475349
Score: 0.951
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.95
Data Source: STRINGDB
LMNB1
Tbio
Novelty: 0.00127348
Score: 0.94
Data Source: STRINGDB
HMGB1
Tbio
Family: TF
Novelty: 0.00043845
Score: 0.939
Data Source: STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.933
Data Source: STRINGDB
HMGA1
Tbio
Family: TF
Novelty: 0.00185669
Score: 0.932
Data Source: Reactome,STRINGDB
HIST1H1D
Tbio
Novelty: 0.00922175
Score: 0.93
Data Source: STRINGDB
Publication Statistics
PubMed Score  2292.42

PubMed score by year
PubTator Score  388.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer