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Tchem
KLK3
Prostate-specific antigen

Protein Classes
Protein Summary
Description
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326003
  • ENSP00000314151
  • ENSG00000142515
  • ENST00000360617
  • ENSP00000353829
  • ENST00000593997
  • ENSP00000472907
  • ENST00000595952
  • ENSP00000471155

Symbol
  • APS
  • APS
  • PSA
  • hK3
  • KLK2A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
transcription factor perturbation
0.97
chemical
0.94
PubMedID
0.94
disease
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20700.16   (req: < 5)
Gene RIFs: 322   (req: <= 3)
Antibodies: 2256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20700.16   (req: >= 5)
Gene RIFs: 322   (req: > 3)
Antibodies: 2256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Metabolism of proteins
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PKNs
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Metabolism of proteins
RHO GTPase Effectors
RHO GTPases activate PKNs
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (179)
1 – 10 of 179
CBWD3
Tdark
Novelty: 0.04264392
p_int: 0.999998927
p_ni: 0.000001073
Data Source: BioPlex
UBA52
Tbio
Novelty: 0.01006012
p_int: 0.999934313
p_ni: 0.000065654
p_wrong: 3.3e-8
Score: 0.537
Data Source: BioPlex,STRINGDB
MIF4GD
Tbio
Novelty: 0.06430868
p_int: 0.999631086
p_ni: 0.000058941
p_wrong: 0.000309973
Score: 0.54
Data Source: BioPlex,STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00285702
p_int: 0.977555227
p_ni: 0.017862843
p_wrong: 0.004581931
Data Source: BioPlex
GRN
Tbio
Novelty: 0.00096763
p_int: 0.947454277
p_ni: 0.052533553
p_wrong: 0.00001217
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00051387
p_int: 0.841115229
p_ni: 0.158884771
Score: 0.296
Data Source: BioPlex,STRINGDB
ERP44
Tbio
Novelty: 0.02934854
p_int: 0.827453434
p_ni: 0.172546566
Data Source: BioPlex
AR
Tclin
Family: NR
Novelty: 0.00013834
Score: 0.997
Data Source: STRINGDB
IGFBP3
Tchem
Novelty: 0.00042672
Score: 0.971
Data Source: Reactome,STRINGDB
IGF1
Tbio
Novelty: 0.00004544
Score: 0.956
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  20700.16

PubMed score by year
PubTator Score  17542.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer