Tbio PROS1 Vitamin K-dependent protein S

Protein Summary

Description

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P07225
• A8KAC9
• D3DN28
• Q15518
• Q7Z715
• Q9UCZ8

Gene Name

• PROS1

Ensembl ID

• ENST00000348974
• ENSP00000330021
• ENSG00000184500
• ENST00000394236
• ENSP00000377783

Symbol

• PROS
• PSA
• PROS
• PS21
• PS22
• PS23
• PS24
• PS25
• THPH5
• THPH6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.94
kinase perturbation	0.88
PubMedID	0.82
disease perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 677.93   (req: < 5)

Gene RIFs: 190   (req: <= 3)

Antibodies: 416   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 677.93   (req: >= 5)

Gene RIFs: 190   (req: > 3)

Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0