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Tbio
PROS1
Vitamin K-dependent protein S

Protein Summary
Description
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis. This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348974
  • ENSP00000330021
  • ENSG00000184500
  • ENST00000394236
  • ENSP00000377783

Symbol
  • PROS
  • PSA
  • PROS
  • PS21
  • PS22
  • PS23
  • PS24
  • PS25
  • THPH5
  • THPH6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.94
kinase perturbation
0.88
PubMedID
0.82
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.1   (req: < 5)
Gene RIFs: 159   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.1   (req: >= 5)
Gene RIFs: 159   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
C4BPB
Tbio
Novelty:  0.0924866
p_int:  0.999314189
p_ni:  0.000685811
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.978077808
p_ni:  0.021922167
p_wrong:  2.5e-8
Data Source:  BioPlex
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.961833083
p_ni:  0.038166896
p_wrong:  2.2e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.908865341
p_ni:  0.09113332
p_wrong:  0.000001339
Data Source:  BioPlex
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.868966653
p_ni:  0.131033338
p_wrong:  9e-9
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.854763125
p_ni:  0.145236875
Data Source:  BioPlex
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
p_int:  0.789299317
p_ni:  0.210700299
p_wrong:  3.84e-7
Score:  0.95
Data Source:  BioPlex,Reactome,STRINGDB
ZPBP2
Tbio
Novelty:  0.06726687
p_int:  0.776042871
p_ni:  0.223957129
Score:  0.295
Data Source:  BioPlex,STRINGDB
BMP4
Tchem
Novelty:  0.00047387
p_int:  0.768656534
p_ni:  0.231343466
Score:  0.272
Data Source:  BioPlex,STRINGDB
GGCX
Tclin
Family:  Enzyme
Novelty:  0.00819484
Score:  0.973
Data Source:  Reactome,STRINGDB
Pathways (63)
Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Complement cascade
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Common Pathway of Fibrin Clot Formation
Complement cascade
Formation of Fibrin Clot (Clotting Cascade)
Gamma carboxylation, hypusine formation and arylsulfatase activation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
5.7
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.7
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein S
VGNC:48907
460533
Macaque
protein S
694845
Mouse
MGI:1095733
19128
Rat
RGD:620971
81750
Dog
protein S
VGNC:53085
478529
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein S
Macaque
protein S
Mouse
Rat
Dog
protein S
Publication Statistics
PubMed Score 372.10
PubMed score by year
PubTator Score 176.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title