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Tbio
PGK2
Phosphoglycerate kinase 2

Protein Summary
Description
Essential for sperm motility and male fertility (PubMed:26677959). Not required for the completion of spermatogenesis (By similarity). This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304801
  • ENSP00000305995
  • ENSG00000170950

Symbol
  • PGKB
  • PGKB
  • PGKPS
  • HEL-S-272
  • dJ417L20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.7
tissue
0.69
cellular component
0.64
gene perturbation
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.2   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.2   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoglycerate kinase 2
VGNC:3613
462757
Macaque
phosphoglycerate kinase 2
706939
C. elegans
171965
S.cerevisiae
S000000605
850370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoglycerate kinase 2
Macaque
phosphoglycerate kinase 2
C. elegans
S.cerevisiae
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P07205-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (17)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (223)
1 – 10 of 223
PGK1
Tchem
Family: Kinase
Novelty: 0.00113494
p_int: 0.999678996
p_ni: 0.000321004
Score: 0.853
Data Source: BioPlex,STRINGDB
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.999640073
p_ni: 0.000188293
p_wrong: 0.000171634
Data Source: BioPlex
ZNF416
Tdark
Family: TF
Novelty: 0.8335845
p_int: 0.998807192
p_ni: 0.001192777
p_wrong: 3e-8
Score: 0.18
Data Source: BioPlex,STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
p_int: 0.997760062
p_ni: 0.002239523
p_wrong: 4.15e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
FAM71D
Tdark
Novelty: 0.76845895
p_int: 0.995060608
p_ni: 0.004938939
p_wrong: 4.53e-7
Score: 0.242
Data Source: BioPlex,STRINGDB
C7orf31
Tdark
Novelty: 1.72375691
p_int: 0.994548862
p_ni: 0.005451123
p_wrong: 1.6e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
ZSCAN12
Tdark
Family: TF
Novelty: 0.33578207
p_int: 0.993945724
p_ni: 0.006054168
p_wrong: 1.08e-7
Data Source: BioPlex
LRRC40
Tdark
Novelty: 2.43377466
p_int: 0.993905029
p_ni: 0.006094849
p_wrong: 1.22e-7
Score: 0.16
Data Source: BioPlex,STRINGDB
FLCN
Tbio
Novelty: 0.0022007
p_int: 0.990745894
p_ni: 0.009193333
p_wrong: 0.000060773
Score: 0.183
Data Source: BioPlex,STRINGDB
POF1B
Tbio
Novelty: 0.1232792
p_int: 0.966099725
p_ni: 0.033900226
p_wrong: 4.9e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  114.20

PubMed score by year
PubTator Score  27.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer