Protein Summary
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
- ENST00000377103
- ENSP00000366307
- ENSG00000178726
- THRM
- TM
- THRM
- AHUS6
- BDCA3
- CD141
- THPH12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
protein domain | 1 | ||
PubMedID | 1 | ||
biological term | 0.97 | ||
disease | 0.9 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2412.43 (req: < 5)
Gene RIFs: 217 (req: <= 3)
Antibodies: 877 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2412.43 (req: >= 5)
Gene RIFs: 217 (req: > 3)
Antibodies: 877 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (148)
1 – 10 of 148
F2
Family: Enzyme
Novelty: 0.00004833
Score: 0.998
Data Source: Reactome,STRINGDB
PROCR
Novelty: 0.00197724
Score: 0.989
Data Source: STRINGDB
PROC
Family: Enzyme
Novelty: 0.00440723
Score: 0.982
Data Source: STRINGDB
F10
Family: Enzyme
Novelty: 0.00063008
Score: 0.96
Data Source: STRINGDB
F5
Novelty: 0.00161772
Score: 0.937
Data Source: STRINGDB
SERPINC1
Novelty: 0.00008721
Score: 0.864
Data Source: STRINGDB
F3
Novelty: 0.00006457
Score: 0.862
Data Source: STRINGDB
TFPI
Novelty: 0.00060355
Score: 0.852
Data Source: STRINGDB
VWF
Novelty: 0.00009007
Score: 0.85
Data Source: STRINGDB
SULT1A3
Family: Enzyme
Novelty: 0.00335383
Score: 0.84
Data Source: STRINGDB
Pathways (13)
Reactome (4)
KEGG (3)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Common Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Gene Ontology Terms (17)
Functions (3)
Components (6)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
thrombomodulin measurement | 1 | 1 | 1 | 88.5 | |||||
blood protein measurement | 1 | 1 | 1 | 83.5 | |||||
1 | 2 | 0 | 2.2 | 24.4 | |||||
cognitive function measurement | 1 | 1 | 1 | 3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
thrombomodulin measurement | 1 | 88.5 | |||||
blood protein measurement | 1 | 83.5 | |||||
0 | 2.2 | 24.4 | |||||
cognitive function measurement | 1 | 3 | |||||
Find similar targets by:
UniProt Keyword
No Header | No Header | ||
|---|---|---|---|
GWAS Trait
No Header | No Header | ||
|---|---|---|---|
MGI Phenotype
No Header | No Header | ||
|---|---|---|---|
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thrombomodulin | VGNC:14481 | 469898 | |||||
Macaque | thrombomodulin | 702132 | ||||||
Mouse | MGI:98736 | 21824 | ||||||
Rat | RGD:621299 | 83580 | ||||||
Dog | thrombomodulin | VGNC:47334 | 474355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thrombomodulin | |||||
Macaque | thrombomodulin | |||||
Mouse | ||||||
Rat | ||||||
Dog | thrombomodulin | |||||
Publication Statistics
PubMed Score 2412.43
PubMed score by year
PubTator Score 1545.51
PubTator score by year