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Tbio
THBD
Thrombomodulin

Protein Summary
Description
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377103
  • ENSP00000366307
  • ENSG00000178726

Symbol
  • THRM
  • TM
  • THRM
  • AHUS6
  • BDCA3
  • CD141
  • THPH12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
PubMedID
1
biological term
0.97
disease
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2412.43   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 877   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2412.43   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 877   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.998
Data Source:  Reactome,STRINGDB
PROCR
Tbio
Novelty:  0.00197724
Score:  0.989
Data Source:  STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.982
Data Source:  STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
Score:  0.96
Data Source:  STRINGDB
F5
Tbio
Novelty:  0.00161772
Score:  0.937
Data Source:  STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.864
Data Source:  STRINGDB
F3
Tchem
Novelty:  0.00006457
Score:  0.862
Data Source:  STRINGDB
TFPI
Tchem
Novelty:  0.00060355
Score:  0.852
Data Source:  STRINGDB
VWF
Tclin
Novelty:  0.00009007
Score:  0.85
Data Source:  STRINGDB
SULT1A3
Tbio
Family:  Enzyme
Novelty:  0.00335383
Score:  0.84
Data Source:  STRINGDB
Pathways (13)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
1
1
88.5
blood protein measurement
1
1
1
83.5
1
2
0
2.2
24.4
cognitive function measurement
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
88.5
blood protein measurement
1
83.5
0
2.2
24.4
cognitive function measurement
1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thrombomodulin
VGNC:14481
469898
Macaque
thrombomodulin
702132
Mouse
MGI:98736
21824
Rat
RGD:621299
83580
Dog
thrombomodulin
VGNC:47334
474355
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thrombomodulin
Macaque
thrombomodulin
Mouse
Rat
Dog
thrombomodulin
Publication Statistics
PubMed Score 2412.43
PubMed score by year
PubTator Score 1545.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title