Protein Summary
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
- ENST00000377103
- ENSP00000366307
- ENSG00000178726
- THRM
- TM
- THRM
- AHUS6
- BDCA3
- CD141
- THPH12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
protein domain | 1 | ||
PubMedID | 1 | ||
biological term | 0.97 | ||
disease | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2412.43 (req: < 5)
Gene RIFs: 217 (req: <= 3)
Antibodies: 877 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2412.43 (req: >= 5)
Gene RIFs: 217 (req: > 3)
Antibodies: 877 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (148)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (13)
Reactome (4)
KEGG (3)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Common Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
thrombomodulin measurement | 1 | 1 | 1 | 88.5 | |||||
blood protein measurement | 1 | 1 | 1 | 83.5 | |||||
1 | 2 | 0 | 2.2 | 24.4 | |||||
cognitive function measurement | 1 | 1 | 1 | 3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
thrombomodulin measurement | 1 | 88.5 | |||||
blood protein measurement | 1 | 83.5 | |||||
0 | 2.2 | 24.4 | |||||
cognitive function measurement | 1 | 3 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thrombomodulin | VGNC:14481 | 469898 | |||||
Macaque | thrombomodulin | 702132 | ||||||
Mouse | MGI:98736 | 21824 | ||||||
Rat | RGD:621299 | 83580 | ||||||
Dog | thrombomodulin | VGNC:47334 | 474355 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thrombomodulin | |||||
Macaque | thrombomodulin | |||||
Mouse | ||||||
Rat | ||||||
Dog | thrombomodulin | |||||
Publication Statistics
PubMed Score 2412.43
PubMed score by year
PubTator Score 1545.51
PubTator score by year
Related Publications
Text Mined References (284)
GeneRif Annotations (217)
Items per page:
0 of 0
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