Protein Summary
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
- ENST00000377103
- ENSP00000366307
- ENSG00000178726
- THRM
- TM
- THRM
- AHUS6
- BDCA3
- CD141
- THPH12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
protein domain | 1 | ||
PubMedID | 1 | ||
biological term | 0.97 | ||
disease | 0.9 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2054.69 (req: < 5)
Gene RIFs: 217 (req: <= 3)
Antibodies: 877 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2054.69 (req: >= 5)
Gene RIFs: 217 (req: > 3)
Antibodies: 877 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (4)
KEGG (3)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Common Pathway of Fibrin Clot Formation | ||||
Reactome | Formation of Fibrin Clot (Clotting Cascade) | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Common Pathway of Fibrin Clot Formation | ||||
Formation of Fibrin Clot (Clotting Cascade) | ||||
Hemostasis | ||||
Gene Ontology Terms (17)
Functions (3)
Components (6)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (148)
1 – 10 of 148
F2
Family: Enzyme
Novelty: 0.00006072
Score: 0.998
Data Source: Reactome,STRINGDB
PROCR
Novelty: 0.00192902
Score: 0.989
Data Source: STRINGDB
PROC
Family: Enzyme
Novelty: 0.00131977
Score: 0.982
Data Source: STRINGDB
F10
Family: Enzyme
Novelty: 0.0007229
Score: 0.96
Data Source: STRINGDB
F5
Novelty: 0.00193441
Score: 0.937
Data Source: STRINGDB
SERPINC1
Novelty: 0.00010169
Score: 0.864
Data Source: STRINGDB
F3
Novelty: 0.00008192
Score: 0.862
Data Source: STRINGDB
TFPI
Novelty: 0.0007551
Score: 0.852
Data Source: STRINGDB
VWF
Novelty: 0.00010911
Score: 0.85
Data Source: STRINGDB
SULT1A3
Family: Enzyme
Novelty: 0.00362442
Score: 0.84
Data Source: STRINGDB
Publication Statistics
PubMed Score 2054.69
PubMed score by year
PubTator Score 1545.51
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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