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Tbio
THBD
Thrombomodulin

Protein Summary
Description
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377103
  • ENSP00000366307
  • ENSG00000178726

Symbol
  • THRM
  • TM
  • THRM
  • AHUS6
  • BDCA3
  • CD141
  • THPH12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
PubMedID
1
biological term
0.97
disease
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2054.69   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 877   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2054.69   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 877   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Common Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Protein-Protein Interactions (148)
1 – 10 of 148
F2
Tclin
Family: Enzyme
Novelty: 0.00006072
Score: 0.998
Data Source: Reactome,STRINGDB
PROCR
Tbio
Novelty: 0.00192902
Score: 0.989
Data Source: STRINGDB
PROC
Tchem
Family: Enzyme
Novelty: 0.00131977
Score: 0.982
Data Source: STRINGDB
F10
Tclin
Family: Enzyme
Novelty: 0.0007229
Score: 0.96
Data Source: STRINGDB
F5
Tbio
Novelty: 0.00193441
Score: 0.937
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00010169
Score: 0.864
Data Source: STRINGDB
F3
Tchem
Novelty: 0.00008192
Score: 0.862
Data Source: STRINGDB
TFPI
Tchem
Novelty: 0.0007551
Score: 0.852
Data Source: STRINGDB
VWF
Tbio
Novelty: 0.00010911
Score: 0.85
Data Source: STRINGDB
SULT1A3
Tbio
Family: Enzyme
Novelty: 0.00362442
Score: 0.84
Data Source: STRINGDB
Publication Statistics
PubMed Score  2054.69

PubMed score by year
PubTator Score  1545.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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