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Tbio
GPX1
Glutathione peroxidase 1

Protein Summary
Description
Protects the hemoglobin in erythrocytes from oxidative breakdown. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally sig ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419349
  • ENSP00000391316
  • ENSG00000233276
  • ENST00000419783
  • ENSP00000407375

Symbol
  • GPXD
  • GSHPX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.99
disease
0.98
transcription factor perturbation
0.96
virus perturbation
0.83


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1272.1   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1272.1   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 1
VGNC:53366
461015
Mouse
MGI:104887
14775
Rat
RGD:2729
24404
Dog
glutathione peroxidase 1
VGNC:41461
442961
Opossum
glutathione peroxidase 1 [Source:HGNC Symbol;Acc:HGNC:4553]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 1
Mouse
Rat
Dog
glutathione peroxidase 1
Opossum
glutathione peroxidase 1 [Source:HGNC Symbol;Acc:HGNC:4553]
Protein Structure (1 Structure, 0 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Fatty acid metabolism
Gene Ontology Terms (45)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (151)
1 – 10 of 151
SOD2
Tbio
Family: Enzyme
Novelty: 0.00084288
Score: 0.988
Data Source: STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.987
Data Source: STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.986
Data Source: STRINGDB
SOD3
Tbio
Family: Enzyme
Novelty: 0.0015758
Score: 0.973
Data Source: STRINGDB
GSS
Tbio
Family: Enzyme
Novelty: 0.03002278
Score: 0.954
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.923
Data Source: STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.919
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.889
Data Source: STRINGDB
GSTM1
Tbio
Family: Enzyme
Novelty: 0.00023264
Score: 0.879
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.878
Data Source: STRINGDB
Publication Statistics
PubMed Score  1272.10

PubMed score by year
PubTator Score  463.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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