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Tbio
CENPB
Major centromere autoantigen B

Protein Summary
Description
Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379751
  • ENSP00000369075
  • ENSG00000125817
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.72
drug perturbation
0.71
tissue
0.7
cellular component
0.66


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.59   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.59   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein B
VGNC:51754
458446
Macaque
centromere protein B
718571
Mouse
MGI:88376
12616
Rat
RGD:1304794
362217
Opossum
centromere protein B
100031122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein B
Macaque
centromere protein B
Mouse
Rat
Opossum
centromere protein B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07199-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (95)
1 – 10 of 95
ZNF264
Tdark
Family: TF
Novelty: 0.32927591
p_int: 0.999993266
p_ni: 0.000006734
Data Source: BioPlex
NOG
Tbio
Novelty: 0.0010373
p_int: 0.999837845
p_ni: 0.000162155
Data Source: BioPlex
ZNF223
Tdark
Family: TF
Novelty: 0.78390275
p_int: 0.999796189
p_ni: 0.000203811
Data Source: BioPlex
ZNF707
Tdark
Family: TF
Novelty: 1.42194815
p_int: 0.999624436
p_ni: 0.000375529
p_wrong: 3.5e-8
Score: 0.155
Data Source: BioPlex,STRINGDB
FEZF1
Tbio
Family: TF
Novelty: 0.01942826
p_int: 0.999083456
p_ni: 0.00091653
p_wrong: 1.4e-8
Score: 0.166
Data Source: BioPlex,STRINGDB
LRRTM4
Tbio
Novelty: 0.07741851
p_int: 0.999023527
p_ni: 0.000976409
p_wrong: 6.4e-8
Data Source: BioPlex
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.998383904
p_ni: 0.001616069
p_wrong: 2.7e-8
Score: 0.152
Data Source: BioPlex,STRINGDB
PES1
Tbio
Novelty: 0.07162845
p_int: 0.994624444
p_ni: 0.005375556
Score: 0.176
Data Source: BioPlex,STRINGDB
TFPI2
Tbio
Novelty: 0.00475383
p_int: 0.992546838
p_ni: 0.007408977
p_wrong: 0.000044186
Data Source: BioPlex
ZNF214
Tbio
Family: TF
Novelty: 0.15323721
p_int: 0.989351651
p_ni: 0.010648045
p_wrong: 3.04e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  270.59

PubMed score by year
PubTator Score  200.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer