Tbio CENPB Major centromere autoantigen B

Protein Summary

Description

Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07199
• Q96EI4

Gene Name

• CENPB

Ensembl ID

• ENST00000379751
• ENSP00000369075
• ENSG00000125817

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.72
drug perturbation	0.71
tissue	0.7
cellular component	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.7   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.7   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (95)

Explore Interacting Targets

1 – 10 of 95

• See Interactions on String-DB

ZNF264

Tdark

Family:  TF

Novelty:  0.32927591

p_int:  0.999993266

p_ni:  0.000006734

Data Source:  BioPlex

NOG

Tbio

Novelty:  0.0010373

p_int:  0.999837845

p_ni:  0.000162155

Data Source:  BioPlex

ZNF223

Tdark

Family:  TF

Novelty:  0.78390275

p_int:  0.999796189

p_ni:  0.000203811

Data Source:  BioPlex

ZNF707

Tdark

Family:  TF

Novelty:  1.42194815

p_int:  0.999624436

p_ni:  0.000375529

p_wrong:  3.5e-8

Score:  0.155

Data Source:  BioPlex,STRINGDB

FEZF1

Tbio

Family:  TF

Novelty:  0.01942826

p_int:  0.999083456

p_ni:  0.00091653

p_wrong:  1.4e-8

Score:  0.166

Data Source:  BioPlex,STRINGDB

LRRTM4

Tbio

Novelty:  0.07741851

p_int:  0.999023527

p_ni:  0.000976409

p_wrong:  6.4e-8

Data Source:  BioPlex

ZNF263

Tbio

Family:  TF

Novelty:  0.098799

p_int:  0.998383904

p_ni:  0.001616069

p_wrong:  2.7e-8

Score:  0.152

Data Source:  BioPlex,STRINGDB

PES1

Tbio

Novelty:  0.07162845

p_int:  0.994624444

p_ni:  0.005375556

Score:  0.176

Data Source:  BioPlex,STRINGDB

TFPI2

Tbio

Novelty:  0.00475383

p_int:  0.992546838

p_ni:  0.007408977

p_wrong:  0.000044186

Data Source:  BioPlex

ZNF214

Tbio

Family:  TF

Novelty:  0.15323721

p_int:  0.989351651

p_ni:  0.010648045

p_wrong:  3.04e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

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Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: pid	FOXM1 transcription factor network	40 targets	PathwayCommons: pid

Name	Explore in Pharos	Explore in Source
FOXM1 transcription factor network	40 targets	PathwayCommons: pid

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (4)

Components (5)

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1 – 4 of 4

GO Term	Evidence	Assigned by
sequence-specific DNA binding	Traceable Author Statement (TAS)	BHF-UCL
chromatin binding	Non-traceable Author Statement (NAS)	UniProtKB
satellite DNA binding	Non-traceable Author Statement (NAS)	UniProtKB
centromeric DNA binding	Inferred by Curator (IC)	BHF-UCL

Disease Associations (null)

No disease associations found

GWAS Traits (12)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	2	5	5		96.4
mean corpuscular volume	EFO_0004526	1	2	2		91.7
mean reticulocyte volume	EFO_0010701	1	2	2		77.1
serum IgM measurement	EFO_0004993	1	1	1		64
lymphocyte count	EFO_0004587	1	1	1		57.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum gamma-glutamyl transferase measurement	EFO_0004532	5		96.4
mean corpuscular volume	EFO_0004526	2		91.7
mean reticulocyte volume	EFO_0010701	2		77.1
serum IgM measurement	EFO_0004993	1		64
lymphocyte count	EFO_0004587	1		57.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ADP-ribosylation
Centromere
Chromosome
Complete proteome
DNA-binding
Isopeptide bond
Methylation
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
lymphocyte count
lymphocyte percentage of leukocytes
mean corpuscular volume
mean reticulocyte volume
neutrophil count
neutrophil percentage of leukocytes
red blood cell density measurement
reticulocyte count
reticulocyte measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	centromere protein B	VGNC:51754	458446
Macaque	centromere protein B		718571
Mouse	centromere protein B	MGI:88376	12616
Rat	centromere protein B	RGD:1304794	362217
Opossum	centromere protein B		100031122

Species	Name	OMA	EggNOG	Inparanoid
Chimp	centromere protein B
Macaque	centromere protein B
Mouse	centromere protein B
Rat	centromere protein B
Opossum	centromere protein B

Publication Statistics

PubMed Score 277.70

PubMed score by year

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PubTator Score 200.43

PubTator score by year

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Related Publications

Text Mined References (46)

GeneRif Annotations (23)

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PMID	Year	Title