You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CENPB
Major centromere autoantigen B

Protein Summary
Description
Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box (PubMed:11726497). May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable). This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379751
  • ENSP00000369075
  • ENSG00000125817
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.72
drug perturbation
0.71
tissue
0.7
cellular component
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.7   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.7   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
ZNF264
Tdark
Family:  TF
Novelty:  0.32927591
p_int:  0.999993266
p_ni:  0.000006734
Data Source:  BioPlex
NOG
Tbio
Novelty:  0.0010373
p_int:  0.999837845
p_ni:  0.000162155
Data Source:  BioPlex
ZNF223
Tdark
Family:  TF
Novelty:  0.78390275
p_int:  0.999796189
p_ni:  0.000203811
Data Source:  BioPlex
ZNF707
Tdark
Family:  TF
Novelty:  1.42194815
p_int:  0.999624436
p_ni:  0.000375529
p_wrong:  3.5e-8
Score:  0.155
Data Source:  BioPlex,STRINGDB
FEZF1
Tbio
Family:  TF
Novelty:  0.01942826
p_int:  0.999083456
p_ni:  0.00091653
p_wrong:  1.4e-8
Score:  0.166
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.999023527
p_ni:  0.000976409
p_wrong:  6.4e-8
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.998383904
p_ni:  0.001616069
p_wrong:  2.7e-8
Score:  0.152
Data Source:  BioPlex,STRINGDB
PES1
Tbio
Novelty:  0.07162845
p_int:  0.994624444
p_ni:  0.005375556
Score:  0.176
Data Source:  BioPlex,STRINGDB
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.992546838
p_ni:  0.007408977
p_wrong:  0.000044186
Data Source:  BioPlex
ZNF214
Tbio
Family:  TF
Novelty:  0.15323721
p_int:  0.989351651
p_ni:  0.010648045
p_wrong:  3.04e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
5
5
96.4
mean corpuscular volume
1
2
2
91.7
mean reticulocyte volume
1
2
2
77.1
serum IgM measurement
1
1
1
64
lymphocyte count
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
5
96.4
mean corpuscular volume
2
91.7
mean reticulocyte volume
2
77.1
serum IgM measurement
1
64
lymphocyte count
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein B
VGNC:51754
458446
Macaque
centromere protein B
718571
Mouse
MGI:88376
12616
Rat
RGD:1304794
362217
Opossum
centromere protein B
100031122
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein B
Macaque
centromere protein B
Mouse
Rat
Opossum
centromere protein B
Publication Statistics
PubMed Score 277.70
PubMed score by year
PubTator Score 200.43
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title