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Tbio
NEFL
Neurofilament light polypeptide

Protein Summary
Description
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610854
  • ENSP00000482169
  • ENSG00000277586

Symbol
  • NF68
  • NFL
  • NFL
  • NF-L
  • NF68
  • CMT1F
  • CMT2E
  • CMTDIG
  • PPP1R110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
hub protein
0.97
PubMedID
0.91
biological process
0.9
kinase
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.55   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 947   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1194.55   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 947   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (25)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Gene Ontology Terms (46)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (159)
1 – 10 of 159
NEFM
Tbio
Novelty: 0.00286577
p_int: 0.999997053
p_ni: 0.000002947
Score: 0.968
Data Source: BioPlex,STRINGDB
VIM
Tbio
Novelty: 0.00046589
p_int: 0.999969372
p_ni: 0.000030628
Score: 0.694
Data Source: BioPlex,STRINGDB
BICD2
Tbio
Novelty: 0.02508993
p_int: 0.999885206
p_ni: 0.000114794
Score: 0.324
Data Source: BioPlex,STRINGDB
NEFH
Tbio
Novelty: 0.00161404
p_int: 0.999791441
p_ni: 0.000208557
p_wrong: 2e-9
Score: 0.71
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.0425174
p_int: 0.99967885
p_ni: 0.00032115
Score: 0.708
Data Source: BioPlex,STRINGDB
BICD1
Tbio
Novelty: 0.02411458
p_int: 0.998638849
p_ni: 0.000321349
p_wrong: 0.001039802
Score: 0.199
Data Source: BioPlex,STRINGDB
RSPRY1
Tdark
Novelty: 0.46153846
p_int: 0.996353123
p_ni: 0.003646877
Score: 0.313
Data Source: BioPlex,STRINGDB
DPP9
Tchem
Family: Enzyme
Novelty: 0.01345112
p_int: 0.993578888
p_ni: 0.006421112
Data Source: BioPlex
RMC1
Tbio
Novelty: 0.02943303
p_int: 0.987325968
p_ni: 0.000282655
p_wrong: 0.012391377
Score: 0.237
Data Source: BioPlex,STRINGDB
MAP7
Tbio
Novelty: 0.02738196
p_int: 0.976732212
p_ni: 0.023267788
Data Source: BioPlex
Publication Statistics
PubMed Score  1194.55

PubMed score by year
PubTator Score  600.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer