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Tchem
LDHB
L-lactate dehydrogenase B chain

Protein Summary
Description
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350669
  • ENSP00000229319
  • ENSG00000111716
  • ENST00000396076
  • ENSP00000379386

Symbol
  • LDH-B
  • LDH-H
  • LDHBD
  • TRG-5
  • HEL-S-281
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
PubMedID
1
transcription factor perturbation
1
disease perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.17   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 392   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.17   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 392   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (229)
LDHC
Tbio
Family:  Enzyme
Novelty:  0.00213484
p_int:  0.999999943
p_ni:  5.7e-8
Score:  0.914
Data Source:  BioPlex,STRINGDB
LDHA
Tchem
Family:  Enzyme
Novelty:  0.0007041
p_int:  0.999166363
p_ni:  0.000833637
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.964
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.958
Data Source:  STRINGDB
LDHD
Tbio
Family:  Enzyme
Novelty:  0.0230704
Score:  0.954
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.952
Data Source:  STRINGDB
G6PD
Tchem
Family:  Enzyme
Novelty:  0.00064455
Score:  0.952
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.944
Data Source:  STRINGDB
ME2
Tbio
Novelty:  0.03635548
Score:  0.943
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
3
6
81.7
serum gamma-glutamyl transferase measurement
1
1
1
72.3
hemoglobin measurement
2
2
2
66.6
C-reactive protein measurement
1
1
1
57.8
mean platelet volume
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
6
81.7
serum gamma-glutamyl transferase measurement
1
72.3
hemoglobin measurement
2
66.6
C-reactive protein measurement
1
57.8
mean platelet volume
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase B
VGNC:5449
465337
Mouse
MGI:96763
16832
Rat
RGD:2997
24534
Dog
lactate dehydrogenase B
477675
Horse
lactate dehydrogenase B
VGNC:19619
100033997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase B
Mouse
Rat
Dog
lactate dehydrogenase B
Horse
lactate dehydrogenase B
Publication Statistics
PubMed Score 414.17
PubMed score by year
PubTator Score 167.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title