Tbio DBI Acyl-CoA-binding protein

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Acyl-coa-binding Protein

Protein / Enzyme Modulator / Acyl-coa-binding Protein

DTO Classes

Protein / Enzyme Modulator / Acyl-coa-binding Protein

Protein Summary

Description

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07108
• B8ZWD2
• B8ZWD6
• B8ZWD7
• P08869
• Q4VWZ6
• Q53SQ7
• Q6IB48
• Q9UCI8
• ACBP

Gene Name

• DBI

Ensembl ID

• ENST00000311521
• ENSP00000311117
• ENSG00000155368
• ENST00000355857
• ENSP00000348116
• ENST00000393103
• ENSP00000376815
• ENST00000409094
• ENSP00000386486
• ENST00000535757
• ENSP00000439012
• ENST00000627093
• ENSP00000486281
• ENST00000627305
• ENSP00000486361

Symbol

• EP
• ACBP
• ACBD1
• CCK-RP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.99
disease perturbation	0.97
histone modification site profile	0.9
small molecule perturbation	0.84

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.11   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.11   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (2)

1 – 2 of 2

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (15)

Reactome (4)

KEGG (1)

PathwayCommons (6)

WikiPathways (4)

Fatty acid metabolism (R-HSA-8978868)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fatty acid metabolism	176 targets	R-HSA-8978868
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Mitochondrial Fatty Acid Beta-Oxidation	37 targets	R-HSA-77289

Name	Explore in Pharos	Explore in Source
Fatty acid metabolism	176 targets	R-HSA-8978868
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Mitochondrial Fatty Acid Beta-Oxidation	37 targets	R-HSA-77289

Gene Ontology Terms (10)

Functions (4)

Components (4)

Processes (2)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
long-chain fatty acyl-CoA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein dimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
benzodiazepine receptor binding	Traceable Author Statement (TAS)	ProtInc
lipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

CRIP1

Tbio

Novelty: 0.01459622

Score: 0.876

Data Source: STRINGDB

LGALS3

Tchem

Novelty: 0.00032884

Score: 0.854

Data Source: STRINGDB

PFDN2

Tbio

Novelty: 0.12469692

Score: 0.827

Data Source: STRINGDB

TSPO

Tchem

Novelty: 0.00074285

Score: 0.825

Data Source: STRINGDB

TSPO

Tchem

Novelty: 0.00074285

Score: 0.825

Data Source: STRINGDB

SCP2

Tchem

Novelty: 0.00215179

Score: 0.769

Data Source: STRINGDB

FDX1

Tbio

Novelty: 0.00142241

Score: 0.754

Data Source: STRINGDB

FDXR

Tbio

Family: Enzyme

Novelty: 0.00218519

Score: 0.75

Data Source: STRINGDB

PFDN5

Tbio

Novelty: 0.09272547

Score: 0.721

Data Source: STRINGDB

ACBD3

Tbio

Novelty: 0.0424778

Score: 0.706

Data Source: STRINGDB

Publication Statistics

PubMed Score  264.11

PubMed score by year

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PubTator Score  234.63

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDA

1-70

MKAYINKVEELKKKYGI

70-87

MSQAEFEKAAEEVRHLKTKPSDEEMLFIYGHYKQATVGDINTERPGMLDFTGKAKWDAWNELKGTSKEDAMKAYINKVEELKKKYGI

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Golgi apparatus
Lipid-binding
Phosphoprotein