Tbio DBI Acyl-CoA-binding protein

Protein Summary

Description

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07108
• B8ZWD2
• B8ZWD6
• B8ZWD7
• P08869
• Q4VWZ6
• Q53SQ7
• Q6IB48
• Q9UCI8
• ACBP

Gene Name

• DBI

Ensembl ID

• ENST00000311521
• ENSP00000311117
• ENSG00000155368
• ENST00000355857
• ENSP00000348116
• ENST00000393103
• ENSP00000376815
• ENST00000409094
• ENSP00000386486
• ENST00000535757
• ENSP00000439012
• ENST00000627093
• ENSP00000486281
• ENST00000627305
• ENSP00000486361

Symbol

• EP
• ACBP
• ACBD1
• CCK-RP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.99
disease perturbation	0.97
histone modification site profile	0.9
small molecule perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Acyl-coa-binding Protein

Protein / Enzyme Modulator / Acyl-coa-binding Protein

DTO Classes

Protein / Enzyme Modulator / Acyl-coa-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.76   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.76   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (70)

Explore Interacting Targets

1 – 10 of 70

• See Interactions on String-DB

CRIP1

Tbio

Novelty:  0.01263063

Score:  0.876

Data Source:  STRINGDB

LGALS3

Tchem

Novelty:  0.00032754

Score:  0.854

Data Source:  STRINGDB

PFDN2

Tbio

Novelty:  0.08537716

Score:  0.827

Data Source:  STRINGDB

B1AH88

Tchem

Novelty:  0.00082324

Score:  0.825

Data Source:  STRINGDB

P30536

Tchem

Novelty:  0.00082324

Score:  0.825

Data Source:  STRINGDB

SCP2

Tchem

Novelty:  0.00183736

Score:  0.769

Data Source:  STRINGDB

FDX1

Tbio

Novelty:  0.00124491

Score:  0.754

Data Source:  STRINGDB

FDXR

Tbio

Family:  Enzyme

Novelty:  0.00171588

Score:  0.75

Data Source:  STRINGDB

PFDN5

Tbio

Novelty:  0.07673574

Score:  0.721

Data Source:  STRINGDB

ACBD3

Tbio

Novelty:  0.02992688

Score:  0.706

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (4)

KEGG (1)

PathwayCommons (6)

WikiPathways (4)

Fatty acid metabolism (R-HSA-8978868)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fatty acid metabolism	176 targets	R-HSA-8978868
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Mitochondrial Fatty Acid Beta-Oxidation	37 targets	R-HSA-77289

Name	Explore in Pharos	Explore in Source
Fatty acid metabolism	176 targets	R-HSA-8978868
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Mitochondrial Fatty Acid Beta-Oxidation	37 targets	R-HSA-77289

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (4)

Components (4)

Processes (2)

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1 – 4 of 4

GO Term	Evidence	Assigned by
long-chain fatty acyl-CoA binding	Inferred from Direct Assay (IDA)	UniProtKB
protein dimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
benzodiazepine receptor binding	Traceable Author Statement (TAS)	ProtInc
lipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative promoter usage
Alternative splicing
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Golgi apparatus
Lipid-binding
Phosphoprotein

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	diazepam binding inhibitor, acyl-CoA binding protein	VGNC:10760	459574
Macaque	diazepam binding inhibitor, acyl-CoA binding protein		698652
Mouse	diazepam binding inhibitor	MGI:94865	13167
Rat	diazepam binding inhibitor, acyl-CoA binding protein	RGD:2490	25045
Dog	diazepam binding inhibitor, acyl-CoA binding protein	VGNC:39782	476115

Species	Name	OMA	EggNOG	Inparanoid
Chimp	diazepam binding inhibitor, acyl-CoA binding protein
Macaque	diazepam binding inhibitor, acyl-CoA binding protein
Mouse	diazepam binding inhibitor
Rat	diazepam binding inhibitor, acyl-CoA binding protein
Dog	diazepam binding inhibitor, acyl-CoA binding protein

Publication Statistics

PubMed Score 284.76

PubMed score by year

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PubTator Score 234.63

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Related Publications

Text Mined References (61)

GeneRif Annotations (23)

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PMID	Year	Title