Tbio DBI Acyl-CoA-binding protein

Protein Summary

Description

Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07108
• B8ZWD2
• B8ZWD6
• B8ZWD7
• P08869
• Q4VWZ6
• Q53SQ7
• Q6IB48
• Q9UCI8
• ACBP

Gene Name

• DBI

Ensembl ID

• ENST00000311521
• ENSP00000311117
• ENSG00000155368
• ENST00000355857
• ENSP00000348116
• ENST00000393103
• ENSP00000376815
• ENST00000409094
• ENSP00000386486
• ENST00000535757
• ENSP00000439012
• ENST00000627093
• ENSP00000486281
• ENST00000627305
• ENSP00000486361

Symbol

• EP
• ACBP
• ACBD1
• CCK-RP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
kinase perturbation	0.99
disease perturbation	0.97
histone modification site profile	0.9
small molecule perturbation	0.84

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Acyl-coa-binding Protein

Protein / Enzyme Modulator / Acyl-coa-binding Protein

DTO Classes

Protein / Enzyme Modulator / Acyl-coa-binding Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.1   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.1   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0