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Tbio
DBI
Acyl-CoA-binding protein

Protein Summary
Description
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311521
  • ENSP00000311117
  • ENSG00000155368
  • ENST00000355857
  • ENSP00000348116
  • ENST00000393103
  • ENSP00000376815
  • ENST00000409094
  • ENSP00000386486
  • ENST00000535757
  • ENSP00000439012
  • ENST00000627093
  • ENSP00000486281
  • ENST00000627305
  • ENSP00000486361

Symbol
  • EP
  • ACBP
  • ACBD1
  • CCK-RP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
disease perturbation
0.97
histone modification site profile
0.9
small molecule perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.11   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.11   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Protein-Protein Interactions (70)
1 – 10 of 70
CRIP1
Tbio
Novelty: 0.01459622
Score: 0.876
Data Source: STRINGDB
LGALS3
Tchem
Novelty: 0.00032884
Score: 0.854
Data Source: STRINGDB
PFDN2
Tbio
Novelty: 0.12469692
Score: 0.827
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00074285
Score: 0.825
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00074285
Score: 0.825
Data Source: STRINGDB
SCP2
Tchem
Novelty: 0.00215179
Score: 0.769
Data Source: STRINGDB
FDX1
Tbio
Novelty: 0.00142241
Score: 0.754
Data Source: STRINGDB
FDXR
Tbio
Family: Enzyme
Novelty: 0.00218519
Score: 0.75
Data Source: STRINGDB
PFDN5
Tbio
Novelty: 0.09272547
Score: 0.721
Data Source: STRINGDB
ACBD3
Tbio
Novelty: 0.0424778
Score: 0.706
Data Source: STRINGDB
Publication Statistics
PubMed Score  264.11

PubMed score by year
PubTator Score  234.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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