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Tchem
EPHX1
Epoxide hydrolase 1

Protein Summary
Description
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272167
  • ENSP00000272167
  • ENSG00000143819
  • ENST00000366837
  • ENSP00000355802
  • ENST00000614058
  • ENSP00000480004

Symbol
  • EPHX
  • EPOX
  • MEH
  • EPHX
  • EPOX
  • HYL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.97
gene perturbation
0.91
biological term
0.84
disease
0.84
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.21   (req: < 5)
Gene RIFs: 166   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 484.21   (req: >= 5)
Gene RIFs: 166   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 157
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
triclocarban
Rendered image for triclocarban
Active Ligands (157)
1 – 10 of 157
CHEMBL1257517
Rendered image for CHEMBL1257517
CHEMBL1257759
Rendered image for CHEMBL1257759
CHEMBL1257880
Rendered image for CHEMBL1257880
US8501783, 1204
Rendered image for US8501783, 1204
US8501783, 1590
Rendered image for US8501783, 1590
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
71.2
sex hormone-binding globulin measurement
2
1
2
56.4
mean corpuscular volume
1
1
1
32.9
red blood cell distribution width
2
1
2
24.5
platelet crit
2
1
2
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
71.2
sex hormone-binding globulin measurement
2
56.4
mean corpuscular volume
1
32.9
red blood cell distribution width
2
24.5
platelet crit
2
15.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epoxide hydrolase 1
VGNC:6790
457777
Macaque
epoxide hydrolase 1
700180
Mouse
MGI:95405
13849
Rat
RGD:2557
25315
Dog
epoxide hydrolase 1
VGNC:40415
480113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epoxide hydrolase 1
Macaque
epoxide hydrolase 1
Mouse
Rat
Dog
epoxide hydrolase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P07099-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (123)
1 – 10 of 123
RAB34
Tbio
Family:  Enzyme
Novelty:  0.03645677
p_int:  0.999998577
p_ni:  0.000001423
Score:  0.243
Data Source:  BioPlex,STRINGDB
MFSD8
Tbio
Novelty:  0.03388459
p_int:  0.999997318
p_ni:  0.000002682
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.988541509
p_ni:  0.011458489
p_wrong:  2e-9
Data Source:  BioPlex
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.980255452
p_ni:  0.019744548
Data Source:  BioPlex
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.979866868
p_ni:  0.020133126
p_wrong:  6e-9
Data Source:  BioPlex
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.952072956
p_ni:  0.047927044
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.949466019
p_ni:  0.050533981
Data Source:  BioPlex
TSPAN17
Tdark
Novelty:  0.51639684
p_int:  0.948751816
p_ni:  0.051248184
Score:  0.159
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.932189188
p_ni:  0.067810812
Data Source:  BioPlex
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.909807475
p_ni:  0.090192524
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  484.21

PubMed score by year
PubTator Score  343.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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