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Tclin
LIPF
Gastric triacylglycerol lipase

Protein Summary
Description
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238983
  • ENSP00000238983
  • ENSG00000182333
  • ENST00000355843
  • ENSP00000348101
  • ENST00000394375
  • ENSP00000377900
  • ENST00000608620
  • ENSP00000477140

Symbol
  • GL
  • HGL
  • HLAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
gene perturbation
0.63
cell type or tissue
0.61
trait
0.61
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.44   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.44   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
chemical structure image
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase F, gastric type
VGNC:7848
466143
Macaque
lipase F, gastric type
693586
Mouse
MGI:1914967
67717
Rat
RGD:708441
50682
Dog
lipase F, gastric type
VGNC:42696
403867
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase F, gastric type
Macaque
lipase F, gastric type
Mouse
Rat
Dog
lipase F, gastric type
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P07098-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary lipid
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary lipid
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
LRSAM1
Tbio
Family: Enzyme
Novelty: 0.04083443
p_int: 1
Score: 0.534
Data Source: BioPlex,STRINGDB
RNF31
Tbio
Family: Enzyme
Novelty: 0.01394304
p_int: 0.999997798
p_ni: 0.000002202
Score: 0.571
Data Source: BioPlex,STRINGDB
SHARPIN
Tbio
Novelty: 0.0197352
p_int: 0.999979492
p_ni: 1.39e-7
p_wrong: 0.000020369
Score: 0.823
Data Source: BioPlex,STRINGDB
MPZL1
Tbio
Novelty: 0.03292508
p_int: 0.994620857
p_ni: 0.005312886
p_wrong: 0.000066257
Score: 0.198
Data Source: BioPlex,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.95831285
p_ni: 0.027232186
p_wrong: 0.014454963
Score: 0.464
Data Source: BioPlex,STRINGDB
NPTX1
Tbio
Novelty: 0.02872516
p_int: 0.856095174
p_ni: 0.14390482
p_wrong: 6e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
LIPE
Tchem
Family: Enzyme
Novelty: 0.00169872
Score: 0.954
Data Source: STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
Score: 0.946
Data Source: STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.926
Data Source: STRINGDB
MGLL
Tchem
Family: Enzyme
Novelty: 0.00196912
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.44

PubMed score by year
PubTator Score  188.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer